CAS: 27460-85-1; (R)-2-((Tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetic Acid

该化合物是属于氨基酸和衍生物类的化学化合物,其结构允许生物系统中的特定互动,使其成为医药化学中有价值的建筑块,在标准实验室条件下一般稳定,但应当谨慎处理,并遵循适当的安全规程.该化合物的溶解性特征可能因使用的溶剂而异,在合成药物中使用时必须考虑到其反应性.

英文名称(R)-2-((Tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetic Acid
中文名称N-Boc-R-对羟基苯甘氨酸
IUPAC名称(R)-2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetic acid
其它别名N-Boc-D-4-Hydroxyphenylglycine; (R)-2-((Tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetic Acid; Boc-(R)-2-Amino-2-(4-Hydroxyphenyl)Acetic Acid; N-Boc-R-4-Hydroxyphenylglycine; N-Tert-Butoxycarbonyl-D-(4-Hydroxyphenyl)Glycine; N-Boc Protected D-4-Hydroxyphenylglycine; N-Boc-4-Hydroxy-D-Phenylglycine; (2R)-2-(4-Hydroxyphenyl)-2-[(2-Methylpropan-2-yl)Oxycarbonylamino]Aceticaci
CAS编号27460-85-1
MFCD编号:MFCD01861312
分子式:C13H17NO5分子量:267.28
产品CID: 1254574
产品分类生物化工 → 氨基酸及其衍生物 → 甘氨酸类衍生物

相似结构搜索
产品信息参考;
InChIKey: LRWJRIFKJPPAPM-SNVBAGLBSA-N
InChI=1S/C13H17NO5/c1-13(2,3)19-12(18)14-10(11(16)17)8-4-6-9(15)7-5-8/h4-7,10,15H,1-3H3,(H,14,18)(H,16,17)/t10-/m1/s1
计算化学: 氢键受体数5.0氢键供体数3.0可旋转键数5.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338
危险品标志Xi

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号22818-40-2 D(-)-对羟基苯甘氨酸 | CAS号762-84-5 N-叔丁基乙酰胺 | CAS号22818-40-2 D(-)-对羟基苯甘氨酸 | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛

合成工艺路线路线简述

合成目标产物 N-Boc Protected D-4-Hydroxyphenylglycine 主要起始原料 Di-Tert-Butyl Dicarbonate And 4-Hydroxy-D-(-)-2-Phenylglycine
(文献来源)合成步骤主要原料 Di-Tert-Butyl Dicarbonate 和 4-Hydroxy-D-(-)-2-Phenylglycine

📜D(-)-对羟基苯甘氨酸以97%的收率获得
参考文献:Salituro,Gino M.;Townsend,Craig A.,J. Amer. Chem. Soc.,112,(1990) N,C. 760-770
标题:Salituro,Gino M.;Townsend,Craig A.,J. Amer. Chem. Soc.,112,(1990) N,C. 760-770

海关参考信息

2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8895741-B2
优先权日:2003-06-03
标题:Process for the synthesis of biaryl oxazolidinones
发明人：WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG
权利人:WU YUSHENG; CHEN SHILI; CHEN YI; HANSELMANN ROGER; LOU RONGLIANG; ZHOU JIACHENG; MELINTA THERAPEUTICS INC
摘要:The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

专利号:US-2013066076-A1
优先权日:2003-06-03
标题:Process for the Synthesis of Biaryl Oxazolidinones

专利号:US-6992097-B2
优先权日:1998-08-18
标题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.