CAS: 259807-47-1; 2-(Pyridin-4-yl)Pyrimidine-5-Carboxylic Acid

相似化合物

259807-46-0 954227-09-9 729589-44-0

上下游产品

2-吡啶-4-基嘧啶-5-羧酸乙酯 Ethyl 2-(4-Pyridyl)-5-Pyrimidinecarboxylate 259807-46-0

📜4-吡啶甲脒置于盐酸,Sodium Ethanolate体系中,用 乙醇,水 用作溶剂,化学反应 13.5H,反应生成2-吡啶-4-嘧啶-5-羧酸
参考文献:Design,Synthesis,And Biological Activity Of Non-Basic Compounds As Factor Xa Inhibitors: Sar Study Of S1 And Aryl Binding Sites
标题:Design,Synthesis,And Biological Activity Of Non-Basic Compounds As Factor Xa Inhibitors: Sar Study Of S1 And Aryl Binding Sites
摘要:Compound 7 Was Identified As The Active Metabolite Of 6 By HPLC And Mass Spectral Analysis. Modification Of Lead Compound 7 By Transformation Of Its N-Oxide 6-6 Biaryl Ring System And Fused Aromatics Produced A Series Of Non-Basic Fxa Inhibitors With Excellent Potency In Anti-Fxa And Anticoagulant Assays. The Optimized Compounds 73B And 75B Showed Sub To One Digit Micromolar Anticoagulant Activity (Ptct2). Particularly,Anti-Fxa Activity Was Detected In Plasma Of Rats Orally Administered With 1 Mg/kg Of Compound 75B. (C) 2005 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2005.04.006