CAS: 2210-74-4; 1-(2-Methoxyphenoxy)-2,3-Epoxypropane

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CAS号90-05-1 愈创木酚 | CAS号106-89-8 环氧氯丙烷 | CAS号3132-64-7 环氧溴丙烷 | CAS号13052-77-2 sodium 2-methox... | CAS号96-23-1 1,3-二氯丙醇 | CAS号79-21-0 过氧乙酸 | CAS号4125-43-3 2-烯丙基苯甲醚 | CAS号95635-55-5 雷诺嗪 | CAS号93-14-1 愈创甘油醚 | CAS号162712-35-8 3-(2-甲氧基苯氧基)-1-... | CAS号77164-20-6 左莫普洛尔 | CAS号66825-05-6 1-(2-aminoethyl... | CAS号91520-01-3 3,4-二氢-8-甲氧基-2H... | CAS号91520-04-6 (8-methoxy-3,4-... | CAS号37708-25-1 1-(tert-butylam... | CAS号5443-29-8 1-Piperazineeth...

木榴油,环氧溴丙烷置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 6.0H,以62%的收率获得愈创木酚缩水甘油醚
参考文献:新系列卡维地洛衍生物的设计,合成和生物学评估,通过阻断机械电传感器通道保护感觉毛细胞免受氨基糖苷类诱导的损伤.
标题:新系列卡维地洛衍生物的设计,合成和生物学评估,通过阻断机械电传感器通道保护感觉毛细胞免受氨基糖苷类诱导的损伤.
摘要:氨基糖苷类 (Ag) 是用于治疗严重细菌感染的广谱抗生素,但具有限制使用的副作用,包括不可逆的听力损失.在这里,我们评估了卡维地洛在小鼠耳蜗培养和体内斑马鱼试验中的耳保护特性,并研究了它的保护机制,我们发现这可能是由毛细胞的机电传感器 (Met) 通道(主要进入途径)的阻断介导的对于 Ag.为了了解卡维地洛的全部耳部保护潜力,制备了一系列 18 种类似物,并评估了它们对 Ag 引起的损伤的作用以及它们对 Met 通道的亲和力.发现一种衍生物在耳蜗培养中比卡维地洛本身具有更大的保护作用,并且与 Met 通道的结合更紧密.
Doi:10.1021/acs.Jmedchem.8B01325

专利信息

专利号:US-9150840-B2
优先权日:2011-08-26
标题 :Isolated bacterial strain of Achromobacter sp. MTCC 5605 and a highly enantioselective epoxide hydrolase isolated therefrom
发明人：KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA
权利人:KAMAL AHMED; KHANNA ROHINI; KUMAR CHITYAL GANESH; SHAIK ANVER BASHA; KUMAR MATAM SHIVA; COUNCIL SCIENT IND RES
摘要:The present invention relates to a novel epoxide hydrolase enzyme which aims to achieve a high degree of resolution towards a broader range of substrates with high enantioselectivity and yields with minimal product inhibition. The invention further relates to a new bacterial strain Achromobacter sp. MTCC 5605 isolated from a petroleum-contaminated sludge sample, capable of producing the said enzyme. It is notable that the enzyme can be used as whole bacterial cell preparation, which allows continuous hydrolysis of substrates at even higher concentration and have an advantage of being recycled. The invention further relates to a process for the hydrolysis of different aryl epoxides which are potential synthons of intermediates for the synthesis of chiral amino alcohols and bioactive compounds like β-blockers.

专利号:US-11219887-B2
优先权日:2017-08-28
标 题 :Method for preparing organic zinc catalyst, organic zinc catalyst prepared by the method and method for preparing polyalkylene carbonate resin using the catalyst
发明人：BANG JUNGUP; PARK KYOSUNG; PARK SEUNG YOUNG; HWANG GYO HYUN; CHOI BYUNG HEE; KIM SUNG-KYOUNG; BANG YONGJU
权利人:LG CHEMICAL LTD
摘要:The disclosed relates to a method for preparing an organic zinc catalyst used in the synthesis of a polyalkylene carbonate resin, an organic zinc catalyst provided therefrom, and a method for preparing a polyalkylene carbonate resin using the catalyst. The organic zinc catalyst according to the present disclosure includes a predetermined amount of Zr on the surface through a simple process, and thus can exhibit improved catalytic activity as compared to a conventional catalyst in the polymerization process for preparing a polyalkylene carbonate resin.

专利号:CN-115651178-B
优先权日:2022-09-29
标题:A kind of synthesis method of polyester with siloxane side groups