CAS: 158922-07-7; 1-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)Piperidine-3-Carboxylic Acid

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193693-68-4 163438-09-3 193693-67-3

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CAS号28920-43-6 芴甲氧羰酰氯(Fm°C-Cl) | CAS号498-95-3 3-哌啶甲酸 | CAS号883106-74-9 N-(6-甲基吡啶-2-基)哌...

合成工艺路线路线简述

    📜氯甲酸-9-芴基甲酯,3-哌啶甲酸置于sodium Carbonate体系中,用 1,4-二氧六环 用作溶剂,化学反应 2.0H,反应生成(+/-)-N-Fmoc-3-哌啶甲酸 Fmoc-Dl-哌啶甲酸
    参考文献:Design And Synthesis Of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists
    标题:Design And Synthesis Of Noncompetitive Metabotropic Glutamate Receptor Subtype 5 Antagonists
    摘要:A Series Of Diaryl Amides Was Designed And Synthesized As Novel Nonethynyl Mglur5 Antagonists. The Systematic Variation Of The Pharmacophoric Groups Led To The Identification Of A Lead Compound That Demonstrated Micromolar Affinity For The Mglur5. Further Optimization Resulted In Compounds With Improved Binding Affinities And Antagonist Profiles,In Vitro. (C) 2006 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2006.04.032

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    专利信息


    专利号:US-5663046-A
    优先权日:1994-06-22
    标 题:Synthesis of combinatorial libraries
    发明人：BALDWIN JOHN J; HORLBECK ERIC G
    权利人:PHARMACOPEIA INC
    摘要:Directly dividing the contents of each sub-pool into the sub-pools for the next step in the synthetic scheme for producing a combinatorial library reduces the standard deviation, sigma , relative to the standard deviation of the split synthesis method for producing such libraries.

    专利号:EP-3515880-B1
    优先权日:2017-03-17
    标题:Methods and compositions for synthesis of encoded libraries
    发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
    权利人:HITGEN INC

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:WO-9535503-A1
    优先权日:1994-06-22
    标题 :Synthesis of combinatorial libraries

    专利号:EP-0766826-A1
    优先权日:1994-06-22
    标题:Synthesis of combinatorial libraries

    专利号:EP-0766826-B1
    优先权日:1994-06-22
    标 题:Synthesis of combinatorial libraries

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    合成参考文献

    合成方法参考DOI号:10.1016/j.bmcl.2006.04.032
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