CAS: 15687-27-1; 2-(4-Isobutylphenyl)Propanoic Acid

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异丁芬酸置于氢氧化钾,氯化亚砜,水,Sodium Amide体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 26.83H,反应生成布洛芬
参考文献:突触前胆碱能调节剂可作为有效的认知增强剂和止痛药.1.热带和2-苯基丙酸酯.
标题:突触前胆碱能调节剂可作为有效的认知增强剂和止痛药.1.热带和2-苯基丙酸酯.
摘要:先前的研究表明,(R)-(+)-Hyscyamine具有镇痛活性,这是由于中央毒蕈碱自体受体拮抗后ach释放增加所致.由于增强中央胆碱能传递可能对认知障碍有益,因此我们操纵了(R)-(+)-水苏胺,合成了几种热带和2-苯基丙酸衍生物,目的是获得能够增加ach释放的药物因此具有镇痛和促智作用.结果表明,几种新化合物确实是有效的镇痛药(镇痛作用与吗啡相当),并且最有效的一种((+/-)-19,Pg9)也具有显着的认知增强特性.
Doi:10.1021/jm00037A022

专利信息

专利号:US-8426630-B2
优先权日:2009-08-31
标题:Method and apparatus for continuous flow synthesis of ibuprofen
发明人：MCQUADE D TYLER; BOGDAN ANDREW; POE SARAH LIHOA
权利人:MCQUADE D TYLER; BOGDAN ANDREW; POE SARAH LIHOA; UNIV FLORIDA STATE RES FOUND
摘要:A multi-step method for the continuous synthesis of ibuprofen or a synthetic precursor of ibuprofen is provided that does not require any intermediate purification or isolation steps and uses reagents compatible with downstream reactions. According to some embodiments, a method is provided wherein isobutylbenzene and a propionyl compound may be converted into a first product in a first Friedel Crafts acylation reaction. The first product may then be converted into a second product in a 1,2-aryl migration reaction. Finally, the second product may be converted into ibuprofen in a hydrolysis reaction. The present invention also provides a method wherein only the first and second reaction steps or only the second and third reaction steps are performed. An apparatus is also provided having two or more microreactors and two or more junctions in particular arrangements for the synthesis of ibuprofen or a synthetic precursor of ibuprofen.

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:US-2012029226-A1
优先权日:2009-02-06
标题:Method for the synthesis of chiral alpha-aryl propionic acid derivatives
发明人：KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
权利人:KAPTEIN BERNARDUS; VLIEG ELIAS; NOORDUIN WILLEM LIEUWE
摘要:The present invention provides a method for the synthesis of optically pure α-aryl propionic acid derivatives comprising subjecting the corresponding racemic α-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-11897914-B2
优先权日:2021-11-29
标题 :Synthesis of 2′ protected nucleosides
发明人：POON WING C; ZOU RUIMING; LAU ALDRICH N K; YU DAVID; Du Gengyu; YAO YUN-CHIAO; ZHAO GANG
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.

专利号:WO-2021033174-A1
优先权日:2020-10-31
标题 :Synthesis, characterization, and biological evaluation of ibuprofen derivative against colon and breast cancer cell-lines
发明人：AL-OBAIDI ZAID MAHDI JABER; AL-ANI AWATEF A IBRAHIM; SHAHEED DHURGHAM QASIM
权利人:AL OBAIDI ZAID MAHDI JABER; AL ANI AWATEF A IBRAHIM; SHAHEED DHURGHAM QASIM
摘要:The synthesis of novel conjugate of ibuprofen with the 6-methyl-N1-(4-(pyridin-3-yl) pyrimidin-2-yl) benzene-1,3-diamine derivative showed a potential antiproliferative activity against both colon cancer and breast cancer cell lines. The chemical structure was characterized and confirmed by spectral (FTIR,1H-NMR and 13C NMR), and the Differential Scanning Colorimetry (DSC) Thermal analyzer. While the biological activity was estimated by Genetic Optimization of Ligand Docking (GOLD) software supplied by Cambridge Crystallographic Data Centre (CCDC) and conducted in vitro with the MTT and the calculation of the IC50. The docking process was successfully performed and the chemical synthesis yield was reasonably high. The spectral interpretations show characteristic identification of the target chemical compound. The results indicated a powerful antitumor drug against breast cancer (MCF7) and colon (HCT116) cell lines. On the other hand, to evaluate the toxicity profile, the Madin-Darby Canine Kidney (MDCK) normal (noncancerous) cell line, was utilized.