CAS: 1436-43-7; Quinoline-2-Carbonitrile

该化合物是一种有机化合物,其特征为quinoline结构,包括一个有引信的苯和环,以及附在quinoline环第二位置的西诺组(-CN),该化合物一般是固体,因其芳香特性而闻名,有助于其稳定性和潜在回活动.该化合物经常用于有机合成,并用作生产各种药品和农用化学品的一个中间体.该西诺组的存在增强了其在核分裂反应中的效用,并成为更复杂的分子的建筑块.此外,2-quinline碳酸三联可展示生物活动,使其对药用化学感兴趣.其溶解性特征各不相同,其有机溶剂中往往比水中更易溶,而水是许多化学化合物的一个常见特征.应当参考安全数据,以便处理与任何化学物质一样,确保采取适当的防范措施.

结构式图片

相似化合物

5470-96-2 93-10-7 89047-45-0

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5382-42-3 喹啉-2-甲酰胺 | CAS号1613-37-2 喹啉-N-氧化物 | CAS号143-33-9 氰化钠 | CAS号7677-24-9 三甲基氰硅烷 | CAS号6560-83-4 2-碘喹啉 | CAS号544-92-3 氰化亚铜 | CAS号2005-43-8 2-溴喹啉 | CAS号151-50-8 氰化钾 | CAS号17954-23-3 1(2H)-Quinoline... | CAS号13721-17-0 1-Benzoyl-1, 2-... | CAS号5760-20-3 2-喹啉甲胺 | CAS号50342-01-3 喹醛酰氯 | CAS号4491-33-2 2-喹啉甲酸乙酯 | CAS号5382-42-3 喹啉-2-甲酰胺 | CAS号63430-79-5 1,2,3,4-四氢喹啉-2-羧酸甲酯 | CAS号101772-02-5 2-(2H-tetrazol-... | CAS号93-10-7 喹哪啶酸 | CAS号13090-26-1 <1,2,4,5>-tetra... | CAS号19575-07-6 喹啉-2-羧酸甲酯 | CAS号120332-75-4 1-aminoquinolin...

合成工艺路线路线简述

    📜Ethyl α-(2-Cyano-1,2-Dihydro-1-Quinolinoxy)Isobutyrate 以 水 用作溶剂,以90%的收率获得2-氰基喹啉
    参考文献:Sliwa,Henri; Randria-Raharimanana,Clarisse; Ouattara,Lassina,Journal Of Heterocyclic Chemistry,1990,Vol. 27,# 3,P. 627-630
    标题:Sliwa,Henri; Randria-Raharimanana,Clarisse; Ouattara,Lassina,Journal Of Heterocyclic Chemistry,1990,Vol. 27,# 3,P. 627-630

    海关参考信息

    专利信息


    专利号:US-2007208164-A1
    优先权日:2006-02-27
    标题:Methods of synthesizing radiolabeled 3-cyano[14C]quinolines
    发明人:OLSZEWSKI JOHN D; MAY MICHAEL K; BERGER DAN M
    权利人:WYETH CORP
    摘要:The present invention is directed to radiolabeled 3-cyanoquinolines of the formula: n n nand methods of synthesizing the same, wherein G 1 , G 2 R 1 , R 4 , Z, X, and n are as defined herein. n nThe present invention is also directed to a radiolabeled intermediate compounds of formula (VII): n n nwherein PG, G 1 , R 1 , R 4 , R 10 , and R 11 are as defined herein, and synthesis of the same.

    专利号:US-3919155-A
    优先权日:1970-12-18
    标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
    发明人:SQUIRE EDWARD NOONAN
    权利人:DU PONT
    摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres and in the presence of from 1 mole percent to 250 mole percent of water based on the molar amount of the aromatic compound.

    专利号:US-4031106-A
    优先权日:1973-12-19
    标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
    发明人:DELPESCO THOMAS WAYNE
    权利人:DU PONT
    摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150 DEG C. to about 500 DEG C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant containing an oxide of lanthanum, samarium, holmium, europium, erbium, yttrium, praseodymium, neodymium, terbium, ytterbium, dysprosium or a mixture of any of them.

    专利号:US-3929889-A
    优先权日:1971-02-16
    标 题 :Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
    发明人:SQUIRE EDWARD NOONAN
    权利人:DU PONT
    摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres.

    专利号:US-4001260-A
    优先权日:1973-12-19
    标 题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia
    发明人:DEL PESCO THOMAS W
    权利人:DU PONT
    摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150° C. to about 500° C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.

    专利号:JP-6594333-B2
    优先权日:2013-12-31
    标 题:Process for the preparation of (E) -4-N, N-dialkylaminocrotonic acid in the form of an HX salt and its use for the synthesis of EGFR tyrosine kinase inhibitors

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Kai Xiong, Et Al. Cyclometalated Iridium(Iii) Complexes As Mitochondria-Targeted Anticancer Agents. Biochimie. 2016 Jun:125:186-94.

    合成参考文献


    参考文献:10.1107/s1600536810032745
    摘要:Loh WS, Quah CK, Hemamalini M, Fun HK. Quinoline-2-carbonitrile-fumaric acid (1/0.5). Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 21;66(Pt 9):o2357.
    参考文献:10.1107/s1600536810033118
    摘要:Loh WS, Quah CK, Hemamalini M, Fun HK. Quinoline-2-carbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 25;66(Pt 9):o2396.
    参考文献:10.1107/s160053681003878x
    摘要:Loh WS, Hemamalini M, Fun HK. 2-Cyano-quinolin-1-ium hydrogen sulfate. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 02;66(Pt 11):o2709.
    参考文献:10.1107/s1600536810039243
    摘要:Loh WS, Hemamalini M, Fun HK. 2-Cyano-quinolin-1-ium nitrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 09;66(Pt 11):o2726–7.
    参考文献:10.1007/s11302-008-9111-5
    摘要:García-Echeverría C. Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways. Purinergic Signalling. 2008 Jun 04;5(1):117–25. doi: 10.1007/s11302-008-9111-5.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知