专利号:US-2007208164-A1 优先权日:2006-02-27 标题:Methods of synthesizing radiolabeled 3-cyano[14C]quinolines 发明人:OLSZEWSKI JOHN D; MAY MICHAEL K; BERGER DAN M 权利人:WYETH CORP 摘要:The present invention is directed to radiolabeled 3-cyanoquinolines of the formula: n n nand methods of synthesizing the same, wherein G 1 , G 2 R 1 , R 4 , Z, X, and n are as defined herein. n nThe present invention is also directed to a radiolabeled intermediate compounds of formula (VII): n n nwherein PG, G 1 , R 1 , R 4 , R 10 , and R 11 are as defined herein, and synthesis of the same.
专利号:US-3919155-A 优先权日:1970-12-18 标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia 发明人:SQUIRE EDWARD NOONAN 权利人:DU PONT 摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres and in the presence of from 1 mole percent to 250 mole percent of water based on the molar amount of the aromatic compound.
专利号:US-4031106-A 优先权日:1973-12-19 标题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia 发明人:DELPESCO THOMAS WAYNE 权利人:DU PONT 摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150 DEG C. to about 500 DEG C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant containing an oxide of lanthanum, samarium, holmium, europium, erbium, yttrium, praseodymium, neodymium, terbium, ytterbium, dysprosium or a mixture of any of them.
专利号:US-3929889-A 优先权日:1971-02-16 标 题 :Synthesis of aromatic amines by reaction of aromatic compounds with ammonia 发明人:SQUIRE EDWARD NOONAN 权利人:DU PONT 摘要:An improved process for producing an aromatic amine is provided in which an aromatic compound is reacted with ammonia in the presence of a conditioned nickel/nickel oxide cataloreactant at a temperature of from about 150*C. to about 500*C. and at a pressure of from about 10 to about 1000 atmospheres.
专利号:US-4001260-A 优先权日:1973-12-19 标 题:Synthesis of aromatic amines by reaction of aromatic compounds with ammonia 发明人:DEL PESCO THOMAS W 权利人:DU PONT 摘要:An improved process is provided for producing an aromatic amine from ammonia and an aromatic compound which comprises reacting the aromatic compound with ammonia at a temperature of from about 150° C. to about 500° C. and at a pressure of from about 10 to about 1000 atmospheres in the presence of a conditioned nickel/nickel oxide/zirconium oxide cataloreactant which has been treated with ammonia prior to introduction of the cataloreactant to the amination reactants.
专利号:JP-6594333-B2 优先权日:2013-12-31 标 题:Process for the preparation of (E) -4-N, N-dialkylaminocrotonic acid in the form of an HX salt and its use for the synthesis of EGFR tyrosine kinase inhibitors
[参考文献]: Kai Xiong, Et Al. Cyclometalated Iridium(Iii) Complexes As Mitochondria-Targeted Anticancer Agents. Biochimie. 2016 Jun:125:186-94.
合成参考文献
参考文献:10.1107/s1600536810032745 摘要:Loh WS, Quah CK, Hemamalini M, Fun HK. Quinoline-2-carbonitrile-fumaric acid (1/0.5). Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 21;66(Pt 9):o2357. 参考文献:10.1107/s1600536810033118 摘要:Loh WS, Quah CK, Hemamalini M, Fun HK. Quinoline-2-carbonitrile. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 25;66(Pt 9):o2396. 参考文献:10.1107/s160053681003878x 摘要:Loh WS, Hemamalini M, Fun HK. 2-Cyano-quinolin-1-ium hydrogen sulfate. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 02;66(Pt 11):o2709. 参考文献:10.1107/s1600536810039243 摘要:Loh WS, Hemamalini M, Fun HK. 2-Cyano-quinolin-1-ium nitrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 09;66(Pt 11):o2726–7. 参考文献:10.1007/s11302-008-9111-5 摘要:García-Echeverría C. Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways. Purinergic Signalling. 2008 Jun 04;5(1):117–25. doi: 10.1007/s11302-008-9111-5.