CAS: 13929-35-6; Rifamycin B

上下游产品

D-Glucose rifamycin S rifamycin SVrifamycin S rifamycin O rifamycin SV Rifamycin-B-pyrrolidid

📜利福霉素置于cytochrome P450 Enzyme Rif16,Ferredoxin Reductasese Fdr,Ferredoxin Sefdx,Transketolase Rif15,3-[(4-氨基-2-甲基-5-嘧啶基)甲基]-4-甲基-5-[4,6,6-三羟基-4,6-二氧-3,5-二氧-4,6-二磷(五)己-1-基]噻唑-3-鎓,氧气,还原型辅酶ii(Nadph)四钠盐,Magnesium Chloride体系中,用 水 用作溶剂,化学反应 8.0H,反应生成利福霉素b
参考文献:解读利福霉素生物合成的后期步骤.
标题:解读利福霉素生物合成的后期步骤.
摘要:利福霉素衍生的药物,包括利福平,利福布汀,利福喷丁和利福昔明,长期以来一直被用作治疗结核病和其他致命感染的一线疗法.然而,导致工业上重要的利福霉素sv和b的生物合成的后期步骤在很大程度上仍是未知的.在这里,我们表征了利福霉素sv,S,L,O和b生物合成基础的反应网络.发现两个亚基转酮酶rif15和细胞色素p450酶rif16分别介导利福霉素中独特的co键形成l和从利福霉素l到b的非典型p450酯至醚的转化.这两个反应都展示了这两个广为研究的酶家族有趣的化学性质.
Doi:10.1038/s41467-018-04772-X

专利信息

专利号:US-4557866-A
优先权日:1984-05-15
标 题 :Process for the synthesis of pyrido-imidazo rifamycins
发明人：CANNATA VINCENZO; TAMAGNONE GIAN F
权利人:ALFA FARMACEUTICI SPA
摘要:A new process for the synthesis of pyrido-imidazo-rifamycins of formula I wherein R is hydrogen or acetyl, R1 and R2 independently represent hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1-3)-alkylamino-(C1-4)-alkyl, (C1-3)-alkoxy-(C1-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, mono- or di-(C1-4)-alkyl-carbamoyl, or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups. The process comprises reacting the rifamycin O of formula II with a 2-aminopyridine of formula III wherein R1 and R2 have the same meanings as before.

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-7510852-B2
优先权日:2002-10-18
标题:Biosynthetic genes and host cells for the synthesis of polyketide antibiotics and method of use
发明人：ROYER MONIQUE; GABRIEL DEAN W; FRUTOS ROGER; ROTT PHILIPPE
权利人:CIRAD; UNIV FLORIDA
摘要:Three gene clusters that together encode albicidin biosynthesis, the complete gene DNA sequences, and the deduced protein sequences for the enzymes and methods for using the DNA sequences are disclosed and discussed as well as methods for plant protection and creating new antibiotics. The novel Albicidin family of antibiotics is disclosed and their structure deduced.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-9150590-B2
优先权日:2011-05-19
标 题 :Process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
发明人：MAZZOLA DISMA; MOIANA SILVIA; COPPI GERMANO
权利人:MAZZOLA DISMA; MOIANA SILVIA; COPPI GERMANO; FRIULCHEM SPA
摘要:Process for the preparation of rifaximin, pseudo-crystalline rifaximin and a new pseudo-crystalline form of rifaximin with fewer impurities obtained thereby.