CAS: 13669-42-6; Quinoline-3-Carboxaldehyde

该化合物是一种有机化合物,其特征为肾脏结构,由诱导苯乙烯和环组成.该化合物在奎诺林环的三处放置一个carboxaldayde功能组(CHO),有助于其反应和在有机合成中的潜在应用.Quinoline-3-carboxalthyde,其典型是黄色至褐色液体或固体,取决于其纯度和形态.它以其芳香特性著称,可以参与各种化学反应,包括核循环毒剂添加和凝聚反应.由于甲醛类的出现,它成为药物,农业化学品和其他有机化合物合成的多功能中间体.此外,对于其生物活动,包括抗微生物和抗沙素特性,经常研究quinoline衍生物.与许多有机化合物一样,处理应该谨慎,考虑到潜在的毒性和环境影响.

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34846-64-5 13669-51-7 6480-68-8

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合成工艺路线路线简述

    喹啉-3-碳酰肼置于吡啶,Sodium Carbonate,乙二醇体系中,化学反应生成3-喹啉甲醛
    参考文献:Cook Et Al.,Journal Of The Chemical Society,1943,P. 413,416
    标题:Cook Et Al.,Journal Of The Chemical Society,1943,P. 413,416

    海关参考信息

    专利信息


    专利号:US-10266565-B2
    优先权日:2011-04-12
    标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
    发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
    权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
    摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

    专利号:US-6133409-A
    优先权日:1996-12-19
    标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
    发明人:SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
    权利人:AVENTIS PHARM PROD INC
    摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

    专利号:EP-0946478-B1
    优先权日:1996-12-19
    标题 :Process for the solid phase synthesis of aldehydes, ketones and hydroxamic acid compounds
    发明人:SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
    权利人:AVENTIS PHARMA INC
    摘要:This invention is directed to processes for the solid-phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds and to polymeric hydroxylamine resin compounds useful therefor.

    专利号:US-6710208-B2
    优先权日:1996-12-19
    标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds
    发明人:SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
    权利人:AVENTIS PHARMA INC
    摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

    专利号:US-5175302-A
    优先权日:1987-07-13
    标 题 :Nucleophilic fluoroalkylation of aldehydes
    发明人:STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

    专利号:US-2011152313-A1
    优先权日:2008-06-20
    标题 :Synthesis of ageladine a and analogs thereof
    发明人:KARUSO PETER HELMUTH; SHENGULE SUDHIR RAMNATHRAO
    权利人:UNIV MACQUARIE
    摘要:The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure R d CHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.
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    主要参考文献

    [参考文献]: M Kumru, Et Al. Theoretical And Experimental Studies On The Vibrational Spectra Of 3-Quinolinecarboxaldehyde. Spectrochim Acta A Mol Biomol Spectrosc. 2012 May:90:28-34.

    合成参考文献


    摘要:Merino, P., Science of Synthesis Knowledge Updates, (2010) 4, 340.
    摘要:Hou, W.; Yang, G.; Xu, H., Science of Synthesis: DNA-Encoded Libraries, (2024) nan, 180.
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