CAS: 13616-82-5; 2,4-Dimethylbenzenethiol

相似化合物

1541-10-2 118-72-9 4001-61-0

上下游产品

CAS号609-60-9 2,4-二甲基苯磺酰氯 | CAS号827-21-4 2,4-二甲苯磺酸钠 | CAS号89816-81-9 Carbonodithioic... | CAS号95-68-1 2,4-二甲基苯胺 | CAS号108-38-3 间二甲苯 | CAS号45869-23-6 2,4-dimethyl-be... | CAS号88-61-9 间二甲苯-4-磺酸 水合物 | CAS号583-70-0 2,4-二甲基溴苯 | CAS号2127-03-9 2,2'-二硫二吡啶 | CAS号603-35-0 三苯基膦 | CAS号508233-74-7 沃替西汀 | CAS号34678-67-6 Benzene, 2,4-di... | CAS号31317-18-7 2,4-二甲基二苯并噻吩 | CAS号16704-47-5 2,4-dimethyldip... | CAS号13616-83-6 1, 2-双(2, 4-二甲基... | CAS号113296-91-6 2-(2,4-dimethyl... | CAS号76293-13-5 2,4-dimethylthi... | CAS号872283-26-6 2,3-二氢-6,8-二甲基-... | CAS号89816-86-4 2-(2,4-dimethyl... | CAS号960203-27-4 氢溴酸沃替西汀

二(2,4-二甲苯基)二硫醚置于sodium Tetrahydroborate,Sodium Hydroxide体系中,用 乙醇,水 用作溶剂,化学反应 3.0H,以90.4%的收率获得2,4-二甲基苯硫酚
参考文献:一种取代的苯硫酚的合成方法
标题:一种取代的苯硫酚的合成方法
摘要:本发明提供一种合成取代的苯硫酚的方法,包括如下步骤:以式v化合物与nahso3或khso3反应合成式iv化合物,式iv化合物与so2反应合成式iii化合物,式iii化合物在naoh溶液下通过nabh4还原合成式ii化合物,最后式ii化合物经酸化得到式i化合物.本发明提供的合成取代的苯硫酚的方法,具有绿色高效,易于工业化应用等优点.

专利信息

专利号:US-10562872-B2
优先权日:2016-02-08
标 题 :Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
发明人：DINESS FREDERIK; MELDAL MORTEN; JACOBSEN CHRISTIAN BORCH
权利人:H LUNDBECK AS
摘要:The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

专利号:US-9493409-B2
优先权日:2013-04-04
标题 :Process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides new intermediate compounds or formulae (III) and (IVa), and salts thereof, and their use in a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine) an experimental drug under development for the treatment of depression and anxiety.

专利号:WO-2014191548-A1
优先权日:2013-05-31
标题:New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), an experimental drug under development for the treatment of depression and anxiety, which comprises the reaction of a compound of formula (VII), or salt thereof, (VII) wherein Q represents S, SO or SO 2 and LG represents a leaving group, with a compound of formula (XI), or salt thereof, (XI) wherein Z represents hydrogen or a protecting group. New intermediate compounds are also provided.

专利号:WO-2015107057-A1
优先权日:2014-01-14
标 题:Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenyl)aniline intermediates
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4- dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)aniline intermediates.

专利号:US-5113019-A
优先权日:1987-11-27
标 题:Process for phenol alkylthiolation and its application to the synthesis of 4-acyl-2-alkylthiophenols
发明人：VOTTERO CATHERINE; LABAT YVES; POIRIER JEAN-MARIE
权利人:ELF AQUITAINE
摘要:The invention relates to the preparation of alkylthiophenols by reaction of a dialkyl disulphide with a phenol. n In the process according to the invention, the reaction is carried out in the presence of aluminum chloride or of ferric chloride in a solvent of the alkylbenzene type or, soley in the case of methylthiolation, in an excess of dimethyl disulphide. n This process makes it possible, in particular to obtain, with a selectivity and in a yield which are excellent, 2-alkylthiophenols which may then be converted into 4-acyl-2-alkylthiophenols by means of a reaction at a temperature ranging from 40° to 100° C. with a complex BF 3 :2RCOOH where R denotes an alkyl or propenyl radical, in a proportion of 10 to 15 moles of complex per mole of 2-alkylthiophenol.

专利号:WO-2015079018-A1
优先权日:2013-11-29
标题:Synthesis of vortioxetine via (2-(piperazine-1 -yl)phenvl)lithium intermediates
发明人：ZUPANCIC BORUT; STERK DAMJAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)lithium intermediates.