CAS: 13512-31-7; Z-Tyr-Ome

相似化合物

1080-06-4 3417-91-2 4326-36-7

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CAS号1080-06-4 L-酪氨酸甲酯 | CAS号501-53-1 氯甲酸苄酯 | CAS号3417-91-2 L-酪氨酸甲酯盐酸盐 | CAS号67-56-1 甲醇 | CAS号1164-16-5 N-苄氧羰基-L-酪氨酸 | CAS号5618-98-4 N-benzyloxycarb... | CAS号13139-17-8 苯甲氧羰酰琥珀酰亚胺 | CAS号60-18-4 L-酪氨酸 | CAS号74-88-4 碘甲烷 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号3417-91-2 L-酪氨酸甲酯盐酸盐 | CAS号5034-68-4 L-酪氨醇 | CAS号1080-06-4 L-酪氨酸甲酯 | CAS号1164-16-5 N-苄氧羰基-L-酪氨酸 | CAS号121778-71-0 Methyl N-[(benz... | CAS号17554-34-6 L-Tyrosine,O-me... | CAS号5068-29-1 (S)-2-((苄氧基)羰基)... | CAS号5545-54-0 O-(叔丁基)-N-Cbz-L-酪氨酸

📜L-酪氨酸置于氯化亚砜,Sodium Carbonate体系中,用 水,丙酮 用作溶剂,化学反应 23.0H,反应生成Z-L-酪氨酸甲酯
参考文献:Tmc-95A 和-B 通过导致 Z-烯酰胺的新反应的全合成.关于 Sar 的一些初步发现
标题:Tmc-95A 和-B 通过导致 Z-烯酰胺的新反应的全合成.关于 Sar 的一些初步发现
摘要:提供了蛋白酶体抑制剂 Tmc-95A 和-B 的全合成的完整说明.合成的一个关键特征涉及通过α-甲硅烷基烯丙基酰胺的热重排安装顺式丙烯酰胺部分.讨论了烯酰胺形成反应的范围和机理.还提供了一些 Sar 研究的初步结果.发现简化的类似物可以保留蛋白酶体抑制的全部效力.
Doi:10.1021/ja049821K

专利信息

专利号:US-5116741-A
优先权日:1988-04-12
标题 :Biosynthetic uses of thermostable proteases
发明人：BRYAN PHILIP N; PANTOLIANO MICHAEL W; ROLLENCE MICHELE L; WONG CHI H
权利人:GENEX CORP
摘要:The invention relates to the novel use of mutants of subtilisin in organic syntheses reactions in non-native environments. Especially the invention relates to methods for the use of mutant subtilisins in organic solvents for the catalysis of reactions involving ester formation and cleavage, including acylations and deacylations, and amidations and deamidations. The methods provide novel strategies which are useful in the synthesis of deoxynucleosides, dideoxynucleosides, peptides, sugars and the like.

专利号:US-9399653-B2
优先权日:2010-03-03
标 题 :Methods and systems for preparing irreversible inhibitors of protein tyrosine phosphatases
发明人：CAIRO CHRISTOPHER WARREN; TULSI NARESH SINGH; DOWNEY ALAN MICHAEL
权利人:CAIRO CHRISTOPHER WARREN; TULSI NARESH SINGH; DOWNEY ALAN MICHAEL; UNIV ALBERTA
摘要:Described herein are the preparation and use of novel bromo-phosphonomethylphenylalanine amino acid derivatives (BrPmp) and BrPmp-containing peptides as specific, irreversible protein tyrosine phosphatase inhibitors, which are suitable for application in peptide synthesis. These derivatives are particularly advantageous since their synthesis is both easy and scalable, and they are suitable for peptide synthesis. The BrPmp derivatives described herein can be appropriately protected to allow for solid phase peptide synthesis (SPPS) and incorporation into peptides for preparation of protein tyrosine phosphatase inhibitors and inhibitor libraries. The peptides and peptide libraries can be used to identify new protein tyrosine phosphatase specific sequences and profile protein tyrosine phosphatase activity in cell lysates, diagnostic samples and biopsy samples.