CAS: 13327-32-7; Beryllium Dihydroxide

⚠️危险化学品目录(2015年版) 致癌性,类别1A
英文名称Beryllium Dihydroxide
中文名称氢氧化铍
IUPAC名称beryllium dihydroxide
其它别名Berylliumhydroxide (6CI,8CI); Beryllium dihydroxide
CAS编号13327-32-7
MFCD编号:MFCD00049856
EINECS号:236-368-6
FDA UNII编号:2X0LRF1T6Q
分子式:BeH2O2分子量:43.03
产品CID: 2498624
产品分类无机化工 → 无机碱

相似结构搜索
产品信息参考;
InChIKey: WPJWIROQQFWMMK-UHFFFAOYSA-L
1S/Be.2H2O/h;2*1H2/q+2;;/p-2
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数0.0

物理性质

熔点138(分解) °C
沸点100 °C at 760mmHg
闪点 °C
密度1.92 g/cm3
PSA:40.46
LogP:-0.3536
溶解性微溶于H2O,碱性溶液;溶于酸溶液
敏感性1.稳定性稳定2.禁配物酸类3.聚合危害不聚合
外观形态无色,正交晶系,无定形粉末或结晶s无定形粉末或晶体
储存条件储存注意事项储存于阴凉、通风的库房。远离火种、热源。包装密封保存。应与酸类、食用化学品分开存放，切忌混储。储区应备有合适的材料收容泄漏物。
产品应用用途:本品制造金属铍和氧化铍.
性质描述氢氧化铍(13327-32-7)的性状:1.本品为白色或黄色粉末;2.熔点138(分解);3.相对密度1.92(水=1).

MSDS等安全信息

警示词Danger
危险描述H350: May cause cancer [Danger Carcinogenicity]
H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
防范说明P203, P260, P264, P270, P280, P318, P319, P405, and P501
UN编号UN 1566
安全声明Once in the body, beryllium acts as a hapten and interacts with human leucocyte antigen (HLA) DP presenting cells in the lungs, becoming physically associated with a major histocompatability (MHC) class II molecule. This MHC class II-beryllium-peptide complex is recognized by the T lymphocyte receptor, triggering CD4+ T lymphocyte activation and proliferation. The resulting inflammatory response is a cell-mediated process orchestrated by cytokines and results in the formation of (usually pulmonary) granulomas. Beryllium's toxicity may be controlled by the iron-storage protein ferritin, which sequesters beryllium by binding it and preventing it from interacting with other enzymes. (L25, A37, A91)
危险类别码May cause severe damage to eyes; May cause beryllium sensitization; [MSDSonline] See Beryllium for one additional linked occupational disease. | The major hazards encountered in the use and handling of beryllium hydroxide stem from its toxicologic properties. Toxic primarily by inhalation and dermal contact, exposure to this white, crystalline substance may occur from its use in the manufacture of beryllium and beryllium oxide. Effects from exposure may include skin ulceration, headache, fatigue, chest pain, shortness of breath, pulmonary edema, and possibly death from heart failure. The OSHA PEL and ACGIH TLV are set at a TWA of 2 ug/cu m. Engineering control of process equipment (eg, enclosure and local exhaust ventilation) should be used to prevent inhalation and skin contact with beryllium hydroxide. In activities where over-exposure is possible, workers should wear a self-contained breathing apparatus. Protective clothing also should be worn, including protective suits (preferably disposable, one-piece, and close-fitting at the ankles and wrists), gloves, hair covering, and overshoes. Work clothes should not be taken home. Eating, smoking, and drinking in beryllium hydroxide work areas should be prohibited. Shipping regulations and other DOT regulatory requirements should be consulted before transport. In cleaning spills of beryllium hydroxide, use a wet mop, or vacuum cleaner equipped with a high efficiency particulate filter. Do not dry sweep, dry mop, or use any such method that would disperse the dust. Before implementing land disposal of waste beryllium hydroxide, consult with environmental regulatory agencies for guidance.

合成工艺路线路线简述

📜Beryllium;Dinitrate 反应生成氢氧化铍
参考文献:Haruta,Masatake;Tsubota,Susumu;Kobayashi,Tetsuhiko;Nakahara,Yoshiko
标题:Haruta,Masatake;Tsubota,Susumu;Kobayashi,Tetsuhiko;Nakahara,Yoshiko

专利信息

专利号:US-2023286918-A1
优先权日:2020-07-02
标题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat
发明人：JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER
权利人:AKEBIA THERAPEUTICS INC
摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.

专利号:US-2025214849-A1
优先权日:2023-12-28
标题:Synthesis of porous crystalline materials in the presence of water-soluble oxidized disulfide oil and fluoride mineralizer
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of porous crystalline materials. The method generally comprises forming a solution of precursors and reagents in effective ratios for a porous crystalline material including a fluoride-containing mineralizer, and water-soluble oxidized disulfide oil. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize porous crystalline materials.

专利号:US-2025214851-A1
优先权日:2023-12-28
标题 :SYNTHESIS OF POROUS CRYSTALLINE MATERIALS IN THE PRESENCE OF FLUORIDE MINERALIZER AND pH-MODIFIED WATER-SOLUBLE OXIDIZED DISULFIDE OIL
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of porous crystalline materials. The method generally comprises forming a solution of precursors and reagents in effective ratios for a porous crystalline material including a fluoride-containing mineralizer, and a pH-modified water-soluble oxidized disulfide oil composition. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize porous crystalline materials.

专利号:US-2025214848-A1
优先权日:2023-12-28
标题:Synthesis of b-oriented mfi in the presence of water-soluble oxidized disulfide oil and fluoride mineralizer
发明人：HODGKINS ROBERT PETER; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are provided for hydrothermal synthesis of b-oriented MFI zeolite. The method generally comprises forming a solution of precursors and reagents in effective ratios for a b-oriented MFI zeolite including a fluoride-containing mineralizer, and water-soluble oxidized disulfide oil. The solution is hydrothermally treated under effective conditions and for an effective time to synthesize b-oriented MFI zeolite.

专利号:WO-2023112055-A1
优先权日:2021-12-15
标题 :New synthetic process design for the synthesis of carboxy tormifene and purity analysis to strengthen antidoping testing
发明人：KUMAR GANGASANI JAGADEESH; PAWAR SACHIN DATTRAM; RADHAKRISHNANAND PULLAPANTHULA; MURTY UPADHYAYULA SURYANARAYANA; SAHU PURAN LAL; DUBEY SACHIN; SAHU KAPENDRA; UPADHYAY AWANISH; KUMAR PRAMOD
权利人:DIRECTOR NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RES GUWAHATI NIPER G; DIRECTOR NAT DOPE TESTING LABORATORY NDTL
摘要:The present invention relates to a process for preparing a compound of formula I: I. The compound of formula I is useful in anti-doping tests.

专利号:US-11958751-B2
优先权日:2022-06-27
标题:Method of synthesizing materials integrating supernatant recycle
发明人：HODGKINS ROBERT P; KOSEOGLU OMER REFA
权利人:SAUDI ARABIAN OIL CO
摘要:Methods are disclosed for synthesizing materials, including an initial synthesis in the presence of WS-ODSO (which can include a pH-modified WS-ODSO composition, in certain embodiments a neutralized WS-ODSO composition), and one or more subsequent syntheses using supernatant (â€œmother liquorâ€?) from a previous synthesis of the same or different materials. The synthesized materials in the initial synthesis and in subsequent synthesis can be the same or different inorganic oxide materials including amorphous oxides, crystalline oxides or oxides of metals. The methods advantageously reduce the amount of utility water required for synthesizing a material and reduce the water waste, and reduce the DSO waste from a refinery and discharge into the environment. In certain embodiments the methods reduce the requirements to procure an alkaline reagent required for synthesizing materials. In certain embodiments, supernatant can be recycled over multiple synthesis batches of the same or different type of materia.