CAS: 1196109-52-0; N-(Pyridin-3-yl)-4-(3-((5-(Trifluoromethyl)Pyridin-2-yl)Oxy)Benzyl)Piperidine-1-Carboxamide
该化合物是一个合成有机化合物,其特征是复杂的分子结构,包括多个芳香环和功能组.该化合物的特征是管状环,它有助于其潜在的生物活动,以及三氟甲基组,它会增强脂性并可能影响其药用植物特性. 环的存在表明它可能与生物目标发生相互作用,从而引起对药用化学的兴趣.其结构表明它可能在不同生物化学途径中作为捆绑或抑制剂.该化合物的溶性,稳定性和再活性受其功能组的影响,这可能影响其在研究或治疗环境中的应用.
- 英文名称N-(Pyridin-3-yl)-4-(3-((5-(Trifluoromethyl)Pyridin-2-yl)Oxy)Benzyl)Piperidine-1-Carboxamide
- 中文名称N-3-吡啶-4-[[3-[[5-(三氟甲基)-2-吡啶]氧基]苯基]甲基]-1-哌啶羧酰胺
- IUPAC名称N-(pyridin-3-yl)-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzyl)piperidine-1-carboxamide
- 其它别名1-Piperidinecarboxamide, N-3-Pyridinyl-4-((3-((5-(Trifluoromethyl)-2-Pyridinyl)Oxy)Phenyl)Methyl)-; N',N'-Dimethylhydrazine
- CAS编号1196109-52-0
- MFCD编号:MFCD18382105
- EINECS号:802-455-8
- FDA UNII编号:Q3PW846TYN
- 分子式:C24H23F3N4O2分子量:456.47
- 产品CID: 259668
- 产品分类生物化工 → 抑制剂 → 代谢(Metabolism)
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2924191000-二甲基甲酰胺
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH. Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. Epub 2011 Jun 30.
2: Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH. Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice. J Pharmacol Exp Ther. 2011 Sep;338(3):795-802. Epub 2011 Jun 9.
3: Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH. The FAAH Inhibitor PF-3845 Acts in the Nervous System to Reverse Lipopolysaccharide-induced Tactile Allodynia in Mice. Br J Pharmacol. 2011 Apr 20. doi: 10.1111/j.1476-5381.2011.01445.x. [Epub ahead of print] Epub 2010 Dec 8.
合成参考文献
参考文献:10.1021/ml300186g
摘要:Keith JM, Apodaca R, Tichenor M, Xiao W, Jones W, Pierce J, Seierstad M, Palmer J, Webb M, Karbarz M, Scott B, Wilson S, Luo L, Wennerholm M, Chang L, Brown S, Rizzolio M, Rynberg R, Chaplan S, Breitenbucher JG. Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate. ACS Med Chem Lett. 2012 Oct 11;3(10):823–7.
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