CAS: 1160-54-9; (S)-1-(2-(((Benzyloxy)Carbonyl)Amino)Acetyl)Pyrrolidine-2-Carboxylic Acid
该化合物是一种含有甘油(Gly)和proline(Pro)的二极分酸衍生物,在N-终点处有一个苯氧碳基(Z)保护组,该化合物因其稳定性和与标准混合试剂的兼容性,广泛用作peptide合成的一个构件.Z组增加了有机溶剂的溶解性,便利了净化和处理.其硬性分泌残留物有助于二级结构的形成,使其对研究浸泡物的顺质特性很有价值.该产品具有高纯度和一贯性,确保研究和制药应用的可靠结果.建议在无水条件下适当储存以保持稳定性.
- 英文名称(S)-1-(2-(((Benzyloxy)Carbonyl)Amino)Acetyl)Pyrrolidine-2-Carboxylic Acid
- 中文名称N-苄氧羰基甘氨酰-L-脯氨酸
- IUPAC名称((benzyloxy)carbonyl)glycyl-L-proline
- 其它别名L-Proline, N-[(Phenylmethoxy)Carbonyl]Glycyl-; Z-Glycyl-L-Proline; (S)-1-(2-(((Benzyloxy)Carbonyl)Amino)Acetyl)Pyrrolidine-2-Carboxylic Acid; Z-Gly-Pro; L-Proline,N-[(Phenylmethoxy)Carbonyl
- CAS编号1160-54-9
- MFCD编号:MFCD00037341
- EINECS号:214-598-8
- 分子式:C15H18N2O5分子量:306.31
- 产品CID: 204774
- 产品分类生物化工 → 氨基酸及其衍生物 → 甘氨酸类衍生物
物理性质
MSDS等安全信息
上下游产品
CAS号2899-60-7 Z-甘氨酸 N-琥珀酰亚胺酯 | CAS号147-85-3 脯氨酸 | CAS号173459-80-8 Benzyl 2-(1H-be... | CAS号1738-86-9 N-苄氧羰基甘氨酸-4-硝基苯酯 | CAS号120584-16-9 3-(Z-Gly)-methy... | CAS号2778-21-4 3-(Z-Gly)-pyrid... | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号66449-90-9 methyl 1-(2-phe... | CAS号501-53-1 氯甲酸苄酯 | CAS号2646-63-1 BENZYLOXYCARBON... | CAS号2441-63-6 H-Gly-Pro-Gly-OH | CAS号704-15-4 甘油-l-脯氨酸 | CAS号13100-15-7 H-Gly-Pro-Pro-OH | CAS号38417-02-6 Z-Gly-Pro-OSu合成工艺路线路线简述
📜L-脯氨酸置于sodium Hydroxide,氯化亚砜,三乙胺,N,N'-二环己基碳二亚胺体系中,用 1,4-二氧六环,二氯甲烷,水 用作溶剂,化学反应 58.0H,反应生成Z-甘氨酸-脯氨酸
参考文献:Synthesis And Neuroprotective Activity Of Analogues Of Glycyl-L-Prolyl-L-Glutamic Acid (Gpe) Modified At The α-Carboxylic Acid
标题:Synthesis And Neuroprotective Activity Of Analogues Of Glycyl-L-Prolyl-L-Glutamic Acid (Gpe) Modified At The α-Carboxylic Acid
摘要:The Synthesis Of Nine Gpe* Analogues,Wherein The Alpha-Carboxylic Acid Group Of Glutamic Acid Has Been Modified,Is Described By Coupling Readily Accessible N-Benzyloxycarbonyl-Glycyl-L-Proline 2 With Various Analogues Of Glutamic Acid. Pharmacological Evaluation Of The Novel Compounds Was Undertaken To Further Understand The Role Of The Glutamate Residue On The Observed Neuroprotective Properties Of The Endogenous Tripeptide Gpe. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2004.10.005
海关参考信息
- 2902300000-甲苯
2905121000-正丙醇
2905130000-正丁醇
2906210000-苄醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-5219741-A
优先权日:1989-09-06
标题:Method of making L-proline using an N-acyl-L-protine acylase
发明人：GROEGER ULRICH; LEUCHTENBERGER WOLFGANG; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:A microbiologically produced, thermostable N-acylproline-acylase and a process for obtaining it from Comamonas testosteroni DSM 5416 and Alcaligenes denitrificans DSM 5417. The enzyme is useful for the synthesis of L-proline from various N-acyl-L-proline derivatives.
专利号:US-3317559-A
优先权日:1963-08-23
标 题:alpha-amino acid esters of n-hydroxysuccinimide and preparation and use in peptide synthesis
发明人：WASHINGTON ANDERSON GEORGE
权利人:AMERICAN CYANAMID CO
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Carboxylic Acids As A Traceless Activation Group For Conjugate Additions: A Three-Step Synthesis Of (+/-)-Pregabalin作者:Lingling Chu,Chisa Ohta,Zhiwei Zuo,David W. C. Macmillan |发布日期:2014.8.6
摘要:Carboxylic Acids As A Traceless Activation Group For Radical Michael Additions Has Been Accomplished Via Visible Light-Mediated Photoredox Catalysis. Photon-Induced Oxidation Of A Broad Series Of Carboxylic Acids, Including Hydrocarbon-Substituted, α-Oxy, And α-Amino Acids, Provides A Versatile Co2-Extrusion Platform To Generate Michael Donors Without The Requirement For Organometallic Activation Or Propagation
合成参考文献
摘要:Wünsch, B.; Geiger, C., Science of Synthesis, (2009) 40, 25.
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