CAS: 104821-25-2; 5-Ethyl-6-Phenyl-5,6-Dihydrophenanthridine-3,8-Diamine

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CAS号1239-45-8 溴化乙啶 | CAS号3546-21-2 ethidium | CAS号854670-32-9 3,8-diamino-5-e...

📜溴化乙啶置于sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,化学反应 24.0H,反应生成二氢乙锭
参考文献:3,8-二氨基-5-乙基-6-苯基-菲啶鎓溴的区域选择性酰化,潜在的新型锥虫病的制备
标题:3,8-二氨基-5-乙基-6-苯基-菲啶鎓溴的区域选择性酰化,潜在的新型锥虫病的制备
摘要:开发了一种方法,该方法可以对色锥虫3,8-二氨基-5-乙基-6-苯基溴化菲(溴化乙锭,,)进行区域选择性修饰.溴化乙锭的直接酰化优先产生c-8氨基取代的衍生物.然而,包括菲环还原,N-酰化和再氧化的反应序列允许c-3和c-8位置的氨基二酰化.制备了一系列c-8和c-3,8分别酰化的二酰化衍生物,旨在提高母体药物的治疗指数.
Doi:10.1016/s0040-4020(01)81017-6

专利信息

专利号:US-11938546-B2
优先权日:2018-10-18
标题:Precision control of large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics
发明人：LO LEU-WEI; CHUANG YAO-CHEN
权利人:NATIONAL HEALTH RES INST; LO LEU WEI
摘要:The present invention relates to a new type of metabolizable flower-like gold nanodandelion (GND), which possesses features: (1) large scale green synthesis with high monodispersity and a circa 100% yield; (2) cellular/physiological degradability; (3) precision control of the shape, petal number and size; (4) highly efficient radiotheranostics encompassing better enhanced CT contrast and pronounced x-ray induced ROS generation than conventional spherical AuNP.

专利号:US-11612610-B2
优先权日:2018-12-14
标题:Mito-magnolol compounds and methods of synthesis and use thereof
发明人：KALYANARAMAN BALARAMAN; ZIELONKA JACEK MICHAL; CHENG GANG; HARDY MICAEL JOËL; OUARI OLIVIER
权利人:MEDICAL COLLEGE WISCONSIN INC; AIX MARSEILLE UNIV; MEDICAL COLLEGE OF WISCONSIN INC
摘要:The present invention provides mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-magnolol compounds in the treatment of cancer, especially anti-cancer therapy or kinase resistant cancers.

专利号:US-2024167006-A1
优先权日:2022-06-09
标题 :High production of recombinant protein by making cell hybrids and enriching for a preferred mitochondrial phenotype
发明人：FORM LAWRENCE; NGO KATHY
权利人:CHO PLUS INC
摘要:This disclosure provides a technology for producing cells and cell lines that are capable of manufacturing a recombinant protein more efficiently and in a more cost effective manner. Cells are engineered or fused together to make a population of cell hybrids. The hybrids are then enriched for a mitochondria phenotype that supports and enhances protein synthesis and secretion. The phenotype may include a higher content of mitochondria per cell, a high or low cellular content of reactive oxygen species (ROS), and/or a high or low mitochondria membrane potential. The hybrids may also be enriched for a high content of endoplasmic reticulum. Producer cell lines obtained in this fashion may produce as much as 10 or 15 times the amount of protein per cell than the parental cell line. The producer cells can be used for efficient manufacture of recombinant proteins suitable for use in any industrial process, such as the making of pharmaceutical agents and food ingredients.

专利号:US-2012329761-A1
优先权日:2010-03-10
标题:Use of tigecycline for treatment of cancer
发明人：SCHIMMER AARON D; SKRTIC MARKO
权利人:SCHIMMER AARON D; SKRTIC MARKO; UNIV HEALTH NETWORK
摘要:Cancer stem cells exhibit different metabolic profiles from other cancer cells, such that they do not readily respond to treatment using conventional chemotherapeutic agents. Studies disclosed herein now demonstrate that the glycylcycline antibiotic tigecycline (a tetracycline derivative) exhibits anti-cancer activity, including activity against cancer stem cells. This anti-neoplastic activity appears to be due to inhibition of mitochondrial protein synthesis in the cancer cells. In preferred embodiments, the cancer to be treated is a hematological cancer, such as leukemia, lymphoma or myeloma.

专利号:WO-2025128096-A1
优先权日:2023-12-13
标题:High production of recombinant protein by making cell hybrids and enriching for a preferred mitochondrial phenotype
发明人：FORMAN LAWRENCE; NGO KATHY
权利人:CHO PLUS INC
摘要:This disclosure provides a technology for producing cells and cell lines that are capable of manufacturing a recombinant protein more efficiently and in a more cost effective manner. Cells are engineered or fused together to make a population of cell hybrids. The hybrids are then enriched for a mitochondria phenotype that supports and enhances protein synthesis and secretion. The phenotype may include a higher content of mitochondria per cell, a high or low cellular content of reactive oxygen species (ROS), and/or a high or low mitochondria membrane potential. The hybrids may also be enriched for a high content of endoplasmic reticulum. Producer cell lines obtained in this fashion may produce as much as 10 or 15 times the amount of protein per cell than the parental cell line. The producer cells can be used for efficient manufacture of recombinant proteins suitable for use in any industrial process, such as the making of pharmaceutical agents and food ingredients.

专利号:TW-202015706-A
优先权日:2018-10-18
标题 :Synthesis of degradable flower-like gold nanoparticles and its use for radiological diagnosis and treatment