CAS: 953039-25-3; 6-Bromo-2-Chloro-8-Fluoroquinazoline
该化合物是一种卤化的五氯硝基苯衍生物,具有多种反应特性,在制药和农用化学合成中成为有价值的中间体,在6,2和8个位置分别存在溴,氯和氟替代物,通过交叉组合,核生殖替代或金属催化反应,可以有选择地发挥功能.该化合物因其电子缺氧的五氮基,特别有助于发展动脉抑制剂和其他生物活性分子.在标准储存条件下,其高纯度和稳定性确保了合成应用的可靠性能.该复合物中存在的结构模型还有利于结构-活动关系研究的进一步衍生.
- 英文名称6-Bromo-2-Chloro-8-Fluoroquinazoline
- 中文名称6-溴-2-氯-8-氟喹
- IUPAC名称6-bromo-2-chloro-8-fluoroquinazoline
- 其它别名2-氯-6-溴-8-氟喹唑啉; Quinazoline, 6-Bromo-2-Chloro-8-Fluoro-
- CAS编号953039-25-3
- MFCD编号:MFCD17016125
- 分子式:C8H3BrClFN2分子量:261.48
- 产品CID: 2006078
- 产品分类有机原料→分子砌块→芳杂环类化合物→喹唑啉类化合物
物理性质
MSDS等安全信息
上下游产品
CAS号1036756-15-6 2(1H)-Quinazoli... | CAS号825-22-9 2-氨基-3-氟苯甲酸 | CAS号874784-14-2 2-氨基-5-溴-3-氟苯甲酸合成工艺路线路线简述
- 1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 5 H,Reflux; Reflux -> Rt1.2 Reagents: Water; Cooled
标题:Preparation Of 6-Phenylquinazoline Derivatives And Related Heterocyclic Compounds As Inhibitors Of Fibroblast Growth Factor Receptor-4 (Fgfr-4)
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 5 H,Reflux
标题:Preparation Of Substituted Acrylamides As Inhibitors Of The Fibroblast Growth Factor Receptor
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 2 H,110 °C
标题:Preparation Of Quinazoline Derivatives And Combination Therapies With Small Molecule Ire1 Inhibitors
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 2 H,110 °C
标题:Preparation Of Substituted Quinazolinamines As Ire1 Small Mol. Inhibitors For Treating Fibrosis
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 2 H,110 °C; 110 °C -> Rt1.2 Solvents: Water; 15 Min,Cooled
标题:Preparation Of Heteroaryl Compounds For Treating Huntington'S Disease
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 2 H,110 °C
标题:Preparation Of Aminocyclohexylaminoquinazolinylpyrimidinylbenzenesulonamide Derivatives For Use As Ire1 Small Molecule Inhibitors
参考文献:World Intellectual Property Organization]
7471-58-1 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 30 Min,Rt -> 110 °C; 110 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 6,Cooled
标题:2-Arylaminoquinazolines As Pdki Inhibitors And Their Preparation And Use In The Treatment Of Proliferative Diseases
参考文献:World Intellectual Property Organization]
1036756-15-6 = 953039-25-3
反应条件:1.1 Reagents: Phosphorus Oxychloride; 30 Min,Rt -> 110 °C; 110 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 6,Cooled
标题:Preparation Of Quinazolines For Pdk1 Inhibition
参考文献:World Intellectual Property Organization]
906811-51-6 + 57-13-6 = 953039-25-3
反应条件:1.1 15 Min,Rt -> 175 °C; 175 °C -> Rt1.2 Reagents: Phosphorus Oxychloride Solvents: Phosphorus Oxychloride; 30 Min,Rt -> 110 °C; 110 °C -> Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Ph 6
标题:Preparation Of Quinazolines For Pdk1 Inhibition
参考文献:World Intellectual Property Organization
📜2-氨基-5-溴-3-氟苯甲酸置于manganese(Iv) Oxide,Dimethyl Sulfide Borane,三氯氧磷体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 22.0H,反应生成 6-溴-2-氯-8-氟喹唑啉
参考文献: Combination Therapies With Ire1 Small Molecule Inhibitors[fr] Polythérapies Avec Des Inhibiteurs à Petites Molécules Ire1
标题: Combination Therapies With Ire1 Small Molecule Inhibitors[fr] Polythérapies Avec Des Inhibiteurs à Petites Molécules Ire1
摘要:本文提供了在联合疗法中使用ire1小分子抑制剂治疗受试者癌症的方法.本文描述的ire1小分子抑制剂可用于治疗实体肿瘤和血液系统肿瘤的联合疗法中.
