CAS: 940289-57-6; Ver 49009

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3-(5-Chloro-2,4-Dihydroxyphenyl)-4-(4-Methoxyphenyl)-1H-Pyrazole-5-Carboxylic Acid 558640-40-7

📜3-(5-Chloro-2,4-Dihydroxyphenyl)-4-(4-Methoxyphenyl)-1H-Pyrazole-5-Carboxylic Acid,乙胺置于n-甲基吗啉,1-羟基苯并三唑一水物,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应生成 Hsp90抑制剂(Ver-49009)
参考文献:Novel,Potent Small-Molecule Inhibitors Of The Molecular Chaperone Hsp90 Discovered Through Structure-Based Design
标题:Novel,Potent Small-Molecule Inhibitors Of The Molecular Chaperone Hsp90 Discovered Through Structure-Based Design
摘要:The Crystal Structure Of A Previously Reported Screening Hit 1 (Cct018159) Bound To The N Terminal Domain Of Molecular Chaperone Hsp90 Has Been Used To Design 5-Amide Analogues. These Exhibit Enhanced Potency Against The Target In Binding And Functional Assays With Accompanying Appropriate Cellular Pharmaeodynamic Changes. Compound 11 (Ver-49009) Compares Favorably With The Clinically Evaluated 17-Aag.
DOI:10.1021/jm050355Z