CAS: 765927-71-7; N-((2S,3R,4S,6R)-2-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-Trihydroxy-13-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,6,8,10,12,14-Heptamethyl-15-Oxo-1-Oxa-6-Azacyclopentadecan-11-yl)Oxy)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-4-yl)Formamide
该化合物是一种结构上改制的甲状腺素衍生物,一种大型滑动抗生素,其特征是去除两个甲基组,并在3 ' N 位置上引入一个形式基组,改变其药用动力学和药用动力特性. 此类修改可以增强它与细菌卵巢的结合性,或提高代谢稳定性,从而有可能导致精细化的抗菌活动或减少抗药性发展. 它可以作为将新型大型滑动衍生物合成用于研究应用,特别是研究结构-活动关系和开发下一代具有最佳功效和安全特征的抗生素的有价值的中间体.
- 英文名称N-((2S,3R,4S,6R)-2-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-Trihydroxy-13-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,6,8,10,12,14-Heptamethyl-15-Oxo-1-Oxa-6-Azacyclopentadecan-11-yl)Oxy)-3-Hydroxy-6-Methyltetrahydro-2H-Pyran-4-yl)Formamide
- 中文名称阿奇霉素杂质 M
- IUPAC名称N-((2S,3R,4S,6R)-2-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadecan-11-yl)oxy)-3-hydroxy-6-methyltetrahydro-2H-pyran-4-yl)formamide
- 其它别名3'-N,N-Di(Desmethyl)-3'-N-Formyl Azithromycin; (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-Ribo-Hexopyranosyl)Oxy]-2-Ethyl-3,4,10-Trihydroxy-3,5,6,8,10,12,14-Heptamethyl-11-[[3,4,6-Trideoxy-3-(Formylamino)-β-D-Xylo-Hexop; Azithromycin Impurity M(Bp); Azithromycin Impurity 13（azithromycin Ep Impurity M）; Azithromycin Ep Impurity M/n-((2S,3R,4S,6R)-2-(((2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-Ethyl-3,4,10-Trihydroxy-13-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,6,8,10,12,14-Heptamethyl-15-Oxo-1-Oxa-6-Azacyclopentadecan-; 3'-N,N-Di(Desmethyl)-3'-N-Formyl Azithromycin(Azithromycin Ep Impurity M); N-Formyl-N-Di(Demethyl)-Azt; 3′-(N,N-Didemethyl)-3′-N-Formylazithromycin
- CAS编号765927-71-7
- FDA UNII编号:T0COS9HZPZ
- 分子式:C37H68N2O13分子量:748.95
- 产品CID: 1758218
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
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