专利号:US-7960589-B2 优先权日:2006-09-06 标 题:Synthesis of sphingosines and their derivatives 发明人:YANG HAO; LIEBESKIND LANNY S 权利人:UNIV EMORY 摘要:Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.
专利号:WO-2008030840-A2 优先权日:2006-09-06 标 题 :Synthesis of sphingosines and their derivatives
专利号:US-2010197954-A1 优先权日:2006-09-06 标 题 :Synthesis of sphingosines and their derivatives
专利号:US-2009137566-A1 优先权日:2005-05-26 标 题 :Substituted Piperdines as Renin Inhibitors 发明人:EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI 权利人:EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI 摘要:The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds preferably have the formula I, n n n n n n n n n n wherein the moieties R1, R2, R11 and W are as defined in the specification.