异戊醇,月桂酸乙烯酯置于二氧化碳体系中,46.02 °C,8.81 Mpa 条件下,反应 3.5H,以98%的收率获得产物月桂酸异戊酯 参考文献:Immobilization Of Lipase On Biocompatible Co-Polymer Of Polyvinyl Alcohol And Chitosan For Synthesis Of Laurate Compounds In Supercritical Carbon Dioxide Using Response Surface Methodology 标题:Immobilization Of Lipase On Biocompatible Co-Polymer Of Polyvinyl Alcohol And Chitosan For Synthesis Of Laurate Compounds In Supercritical Carbon Dioxide Using Response Surface Methodology 摘要:Biocompatible Co-Polymer Matrix Has Great Importance For Enzyme Immobilization And Subsequent Bio-Catalytic Applications To Synthesize Important Organic Moieties. Citronellyl Laurate Is A Fatty-Acid-Ester Having Pleasant Fruity Aroma And Widely Used As/in Emulsifier,Lubricant In Textile,Paint Or Ink-Additives,Surfactants,Perfumery And Food-Flavouring Ingredient. In Present Study,Burkholderia Cepacia Lipase (Bcl) Was Immobilized On Biodegradable Co-Polymer Of Chitosan (Chi) And Polyvinyl Alcohol (Pva). The Synthesized Bio-Catalyst {pva:Chi:Bcl (6:4:2.5)} Was Characterized By Sem,Tga,Lipase Assay And Protein-Content Analysis. This Biocatalyst Was Applied To Synthesize Citronellyl Laurate In Supercritical Carbon-Dioxide (Sc-Co2) Using Response Surface Methodology With Five-Factor-Three-Level Box-Behnken-Design To Optimize Reaction Parameters (Citronellol: 8.5 Mmol; Vinyl Laurate: 19.87 Mmol; Biocatalyst: 175.6 Mg; Temperature: 46.02 Degrees C; Pressure: 8.81 Mpa) Which Provided 94 +/-1.52% Yield. The Protocol Is Extended To Synthesize Various Important 12 Laurate Compounds With Excellent Yield (90-98%) And Noteworthy Recyclability (Upto Studied 5 Recycles). Interestingly,Immobilized Pva/chi/lipase Biocatalyst Showed 4-Fold Higher Bio-Catalytic Activity Than Free Lipase In Sc-Co2. Moreover,The Biocatalyst Activity Assessment Study Showed Remarkable Activity-Stability Of Immobilized Biocatalyst In Sc-Co2 Media As Compared To Free Enzyme. Thus,Present Protocol Demonstrated Potential Biocatalytic Applications For Synthesis Of Important Laurate Compounds With Excellent Recyclability In Sc-Co2 As Greener Biocatalyst And Reaction Medium. (C) 2015 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Procbio.2015.04.019
专利号:US-7722904-B2 优先权日:2007-11-01 标 题 :Compositions and methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid 发明人:SCHNEIDER LOUISE M; PUSATERI DONALD J; LA TOM Q 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:A method for improving the appearance, texture and/or moisture of skin comprising administering a composition comprising Chia Seed oil, Opuntia ficus Indica extract, or both to stimulate collagen or hyaluronic acid synthesis, or decrease Interleukin-1b synthesis, in the skin.
专利号:US-2008108681-A1 优先权日:2006-10-27 标题:Use of allantoin as a pro-collagen synthesis agent in cosmetic compositions 发明人:SCIMECA JOHN V; FAST DAVID J; ZIMMERMAN AMY C 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:Compositions comprising allantoin and an acceptable carrier and methods of using such compositions to increase pro-collagen synthesis in skin are disclosed. Compositions of the present invention may be used to decrease the signs of skin aging such as wrinkles and fine lines. Compositions of the present invention may be topically administered, orally administered or parenterally, such as administration by injection. When topically administered, additive ingredients such as penetration enhancers, fragrances, and moisturizers and cosmetic adjuvants may be included in compositions of the present invention.
专利号:US-7955628-B2 优先权日:2004-12-14 标题 :Methods of using nonpolar grape seed extracts to stimulate tyrosinase expression or melanin synthesis 发明人:DUVEL LANE A; CHANDRA AMITABH 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering to the cell at least one non polar grape seed extract, for example, a nonpolar grape seed extract obtained using hexane as an extraction solvent. The nonpolar grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.
专利号:US-2007036742-A1 优先权日:2005-08-09 标题 :Methods and compositions for modulating hair growth or regrowth 发明人:ROUFS JAMES B; DUVEL LANE A; FAST DAVID J; GLYNN KELLY M 权利人:ACCESS BUSINESS GROUP INT LLC 摘要:The present invention relates to compositions and methods for modulating hair growth or regrowth. The compositions of the present invention comprise extracts of one or more of the following: Boswellia serrata, Undaria pinnatifida, green tea (e.g., Camellia sinensis ), shiso, Pureraria mirifica, luteolin (e.g. Perilla ocymoides leaf extract), astilbin, vitamin E, amentoflavone, tetrahydropiperine, licochalcone, astaxanthin, red clover, Brassica juncea, unfermented green rooibos, enzyme CoQ10, salvia, ximenynic acid, hops oleoresin, apple, soy, saw palmetto, or ellagic extract, or any derivative thereof. In particular, the compositions and methods of the present invention can be used to stimulate or increase hair growth and/or prevent or slow the loss of hair by having one or more of the following functions: (a) inhibiting synthesis of DHT; (b) inhibiting proteasomal activity; (c) inhibiting IL-1 activity; (d) increasing vascularization; (e) increasing expression of vascular endothelial growth factor; (f) increasing expression of keratinocyte growth factor; (g) inhibiting inflammation; or (h) acting as an antibacterial.
专利号:US-12274729-B2 优先权日:2022-01-03 标 题:Formulations and methods for skin care or hyaluronic acid synthesis 发明人:PAPPAS APOSTOLOS; ILNYTSKA OLGA 权利人:AMILYFE LLC 摘要:Cosmetic and pharmaceutical formulations comprising specific amino acid combinations are described herein. Such formulations strengthen and enhance skin epithelial cell barrier function, thereby reducing moisture loss from the skin and restoring skin's structural integrity, epithelial differentiation, intercellular adhesion, and intracellular signaling and/or promoting maintenance of these features. Formulations described here comprise a therapeutically effective amount of free amino acids or a peptide combination of amino acids and either a therapeutically effective amount of a plant extract for skin barrier repair or a therapeutically effective amount of a retinoid for improving skin moisture. Also provided are injectable formulations described here for treating a subject suffering from osteoarthritis or symptoms thereof. Methods for administering these formulations for cosmetic and/or therapeutic purposes and uses thereof for same are also described herein, including the use thereof in the preparation of medicaments.
专利号:WO-2009058613-A1 优先权日:2007-11-01 标 题 :Methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid