CAS: 587-03-1; M-Tolylmethanol

该化合物是一种含有分子式C8H10O的芳香醇.一种明显,无色的黄色液体,具有温和的花粉味.这种化合物通常用作有机合成的中间体,特别是在香料,药品和农用化学剂的生产中.它的苯基氢氧基组使它成为进一步功能化的多用途建筑块,例如酯化或氧化.苯环上的甲基替代会增强它的稳定性和影响电子动力替代反应中的再活动.3-甲基苯醇在有机溶剂中溶解,但水中的溶性有限,因此适合非水溶性应用.适当的处理要求对芳香酒精采取标准的安全防范措施.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号620-23-5 间甲基苯甲醛 | CAS号99-04-7 间甲基苯甲酸 | CAS号134-62-3 避蚊胺 | CAS号100-81-2 间甲基苄胺 | CAS号99-36-5 3-甲基苯甲酸甲酯 | CAS号108-38-3 间二甲苯 | CAS号134390-32-2 (3-methylphenyl... | CAS号632-46-2 2,6-二甲基苯甲酸 | CAS号591-17-3 3-溴甲苯 | CAS号14503-41-4 4-methylbenzene... | CAS号108-38-3 间二甲苯 | CAS号1875-89-4 3-甲基苯乙醇 | CAS号108-88-3 甲苯 | CAS号620-23-5 间甲基苯甲醛 | CAS号99-36-5 3-甲基苯甲酸甲酯 | CAS号618-47-3 间甲基苯甲酰胺 | CAS号620-50-8 1,3-bis(3-methy... | CAS号15429-17-1 N-苄-1-(3-甲基苯)甲胺 1盐酸盐 | CAS号99-04-7 间甲基苯甲酸

合成工艺路线路线简述

    3-甲基苄胺置于sodium Hydroxide体系中,用 甲醇,水 作为反应溶剂,化学反应 2.0H,以79%的收率获得产物3-甲基苄醇
    参考文献:碱催化的苄胺直接转化为苄醇
    标题:碱催化的苄胺直接转化为苄醇
    摘要:在碱性催化剂存在下,在过热的甲醇水溶液中将苄胺直接转化为苯甲醇.此过程很简单,将为苯甲醇(例如二甲苯二醇)提供替代的工业途径. 醇类-胺类-催化-取代-固相合成
    DOI:10.1055/s-0031-1290595

    海关参考信息

    专利信息


    专利号:US-2010143980-A1
    优先权日:2007-02-22
    标题:Synthesis of novel xylosides and potential uses thereof
    发明人:BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
    权利人:BALAGURUNATHAN KUBERAN; MANIVANNAN ETHIRAJAN; XYLOPHONE V VICTOR; TRAN VY MY; NGUYEN KHIEM
    摘要:The present invention includes a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, the xyloside having a chemical structure of one of Formula (1), Formula (2), Formula (3), Formula (4), Formula (5), Formula (6), Formula (7), Formula (8), Formula (9), or Formula (10) as shown herein. Also, the present invention includes a method of making a xyloside for use in inducing synthesis of a glycosaminoglycan in a cell, wherein the method is performed with “Clickâ€? chemistry. Additionally, the present invention includes a method of administering a xyloside so as to induce synthesis of a glycosaminoglycan in a cell.

    专利号:US-6765117-B2
    优先权日:1997-10-24
    标题:Process for stereoselective synthesis of prostacyclin derivatives
    发明人:MORIARTY ROBERT M; PENMASTA RAJU; GUO LIANG; RAO MUNAGALA S; STASZEWSKI JAMES P
    权利人:UNITED THERAPEUTIC CORP
    摘要:An improved method is described for making 9-deoxy-PGF 1 -type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds. The invention also relates to novel intermediates prepared during the synthesis of the 9-deoxy-PGF 1 -type compounds.

    专利号:US-5637757-A
    优先权日:1995-04-11
    标 题 :One-pot synthesis of ring-brominated benzoate compounds
    发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
    权利人:GREAT LAKES CHEMICAL CORP
    摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

    专利号:US-2002173672-A1
    优先权日:1997-10-24
    标 题:Process for stereoselective synthesis of prostacyclin derivatives

    专利号:WO-2008103618-A1
    优先权日:2007-02-22
    标 题 :Synthesis of novel xylosides and potential uses thereof

    专利号:US-7612064-B2
    优先权日:2003-05-26
    标题:Sulfopyrroles
    发明人:EBERLE MARTIN; ERMERT PHILIPP; OBRECHT DANIEL; LACH FRANK; LUTHER ANATOL; BACHMANN FELIX; STREBEL ALLESSANDRO
    权利人:TAKEDA PHARMACEUTICAL
    摘要:The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.
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    主要参考文献

    [参考文献]: Chun Chau Sze, Et Al. Integration Of Global Regulation Of Two Aromatic-Responsive Sigma(54)-Dependent Systems: A Common Phenotype By Different Mechanisms. J Bacteriol. 2002 Feb;184(3):760-70.
    [参考文献]: Dockyu Kim, Et Al. Benzylic And Aryl Hydroxylations Of M-Xylene By O-Xylene Dioxygenase From Rhodococcus Sp. Strain Dk17. Appl Microbiol Biotechnol. 2010 May;86(6):1841-7.
    [参考文献]: K M Engstrm, Et Al. Urinalysis Of Minor Metabolites Of Ethylbenzene And M-Xylene. Scand J Work Environ Health. 1984 Apr;10(2):75-81.
    [参考文献]: Rafael Silva-Rocha, Et Al. The Logic Layout Of The Tol Network Of Pseudomonas Putida Pww0 Plasmid Stems From A Metabolic Amplifier Motif (Mam) That Optimizes Biodegradation Of M-Xylene. Bmc Syst Biol. 2011 Nov 11:5:191.
    [参考文献]: S Fraile, Et Al. Monitoring Intracellular Levels Of Xylr In Pseudomonas Putida With A Single-Chain Antibody Specific For Aromatic-Responsive Enhancer-Binding Proteins. J Bacteriol. 2001 Oct;183(19):5571-9.

    合成参考文献


    摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 215.
    摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 354.
    摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2014) 2, 428.
    摘要:Wu, X.; Xiao, J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 257.
    摘要:Wu, X.; Xiao, J., Science of Synthesis: Water in Organic Synthesis, (2012) 1, 268.
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