CAS: 4255-62-3; 4,4-Dimethylcyclohexanone

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CAS号1073-13-8 4,4-二甲基-2-环己基-1-酮 | CAS号1112-35-2 3,3-DIMETHYL-1,... | CAS号590-66-9 1,1-二甲基环己烷 | CAS号60187-76-0 5,5-dimethyl-2-... | CAS号850859-15-3 6-hydroxy-N-met... | CAS号850859-16-4 6-iodo-N-methox... | CAS号55134-05-9 4,4-Dimethylpim... | CAS号53120-74-4 3,3-二甲基戊烷-1,5-二醇 | CAS号1053265-66-9 2-溴-5,5-二甲基-1-环... | CAS号55739-89-4 2-ethyl-4,4-dim... | CAS号595-46-0 二甲基丙二酸 | CAS号4839-46-7 3,3-二甲基戊二酸 | CAS号932-01-4 4,4-二甲基环己-1-醇 | CAS号681-57-2 2,2-二甲基戊二酸 | CAS号1073-13-8 4,4-二甲基-2-环己基-1-酮 | CAS号597-43-3 2,2-二甲基琥珀酸 | CAS号3419-71-4 1,4,4-trimethyl... | CAS号313511-16-9 4-(4,4-二甲基环己基)苯酚

4,4-Dimethyl-Heptanedioic Acid Diethyl Ester置于barium Dihydroxide体系中,化学反应生成 4,4-二甲基环己酮
参考文献:Contribution To The Multiplanar Isomerism Of Cyclohexanes
标题:Contribution To The Multiplanar Isomerism Of Cyclohexanes
摘要:
DOI:10.1021/ja01296A031

专利信息

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-5698600-A
优先权日:1995-10-24
标题:Process for the production of bisphenols with the use of new cocatalysts
发明人：WULFF CLAUS; FENNHOFF GERHARD; EITEL ALFRED
权利人:BAYER AG
摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones with concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion-pair bond to a matrix insoluble in the reaction medium.

专利号:US-5190867-A
优先权日:1986-05-08
标题:Process for the preparation of R-2,2-R1,R2 -1,3-dioxolane-4-methanol
发明人：BERTOLA MAURO A; MARX ARTHUR F; KOGER HEIN S; CLAASSEN VOLKERT P; PHILLIPS GARETH T
权利人:SHELL INTERNATIONAL PETROLEUM
摘要:Process for the preparation of R-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol wherein R 1 and R 2 are H or alkyl groups or wherein R 1 and R 2 together with the carbon atom to which they are attached form a carbocyclic ring by subjecting a mixture of R- and S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol to the action of a micro-organism or substances derived therefrom having the ability for stereoselective consumption of S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol preferably until at least 80 wt % and more preferably all the S-2,2-R 1 ,R 2 -1,3-dioxolane-4-methanol is consumed. Various micro-organisms of the genus Rhodococcus, Nocardia and Corynebacterium are disclosed as suitable for the purpose. The R-isomer is a valuable intermediate for stereospecific synthesis of various biologically active compounds including S-metoprolol.

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:WO-2023081730-A1
优先权日:2021-11-03
标 题:4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer
发明人：ELZEIN ELFATIH; LIU JIWEN
权利人:TEON THERAPEUTICS INC
摘要:The present invention relates to 82 specific 4-hydroxy-2-oxo-1,2- dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid CB2 receptor modulators for the treatment of cancer, e.g. to 6-(4- fluorophenyl)-4-hydroxy-1-(2-(4-methylpiperazin-1-yl)ethyl)-2-oxo-N- (spiro[2.3]hexan-5-yl)-1,2-dihydro-1,8-naphthyridine-3-carboxamide (example 1, compound 1) The present description discloses the synthesis and characterisation of the 82 claimed compounds as well as biological assays thereof.

专利号:US-6320049-B1
优先权日:1997-08-05
标题 :Alpha 1a adrenergic receptor antagonists
发明人：SIDLER DANIEL R; LARSEN ROBERT D; LI WENJIE
权利人:MERCK & CO INC
摘要:This invention relates to crystalline pharmaceutically acceptable salts of an alpha 1a adrenergic receptor antagonist, Compound A, which are useful in the treatment of benign prostatic hyperplasia. Pharmaceutical compositions employing the crystalline salts, and processes for making and using the crystalline salts and pharmaceutical compositions of Compound A are also disclosed. This invention further relates to a process for obtaining enantiomerically pure intermediate useful for the synthesis of end product alpha 1a adrenergic receptor antagonists. The end product compounds are useful for the treatment of benign prostatic hyperplasia and for relaxing lower urinary tract tissue. The invention also relates to a process for preparing a class of dihydropyrimidinone compounds of which Compound A is a member, wherein the process involves deprotonating a dihydropyrimidinone compound and then coupling the deprotonated derivative with a primary amine.