CAS: 40438-64-0; 4-(Dicyclohexylphosphino)-N,N-Dimethylaniline

Dicyclohexylphosphonium Chloride,N,N-二甲基苯胺置于4-二甲氨基吡啶体系中,用 甲苯 作为反应溶剂,化学反应 12.0H,以97%的收率获得产物二环己基(4-(N,N-二甲基氨基)苯基)膦
参考文献:一种合成[4-(N,N-二甲氨基)苯基]二烷基膦 的方法
标题:一种合成[4-(N,N-二甲氨基)苯基]二烷基膦 的方法
摘要:本发明公开了一种合成[4‑(N,N‑二甲氨基)苯基]二烷基膦的方法,属于有机合成领域.该方法在无水无氧氛围中,以n,N‑二甲基苯胺为原料,4‑二甲氨基吡啶为碱,在乙酸亚铜的催化作用下,与二烷基氯化膦反应反应生成[(4‑n,N‑二甲氨基)苯基]二烷基膦.与现有技术相比本发明反应条件温和,操作简单,产率高,原料简单易得,降低了生产成本,适合工业化生产.

专利信息

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.

专利号:CA-2875508-C
优先权日:2012-06-05
标 题:Synthesis of hepatitis c antiviral fluorenyl-benzimidazole derivatives compounds

专利号:JP-2018145200-A
优先权日:2012-06-05
标题:Synthesis of antiviral compounds

专利号:US-2013324740-A1
优先权日:2012-06-05
标题:Synthesis of antiviral compound

专利号:US-2015232453-A1
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound

专利号:KR-20200066376-A
优先权日:2012-06-05
标 题:Synthesis of antiviral compound