CAS: 39028-27-8; 2,5-Dioxopyrrolidin-1-Yl 2-Iodoacetate

相似化合物

14464-29-0 27243-15-8 42014-51-7

上下游产品

1-hydroxy-pyrrolidine-2,5-dione Iodoacetic acid1-(N-carbobenzyloxy-L-alanyl-L-alanyl-L-phenylalanyl)-2-iodoacetyl hydrazine 75H99IN26O13C75H99IN26O13 21H29IN4O8C21H29IN4O8 1,3,5-tris(iodoacetamidomethyl)-2,4,6-triethylbenzene

N-羟基丁二酰亚胺,碘乙酸置于n,N'-二异丙基碳二亚胺体系中,用 乙酸乙酯 作为反应溶剂,化学反应 6.0H,以86%的收率获得产物碘乙酸 N-羟基琥珀酰亚胺酯
参考文献:易于操作的phospho标记荧光香豆素,可通过质谱增强结合物的检测†
标题:易于操作的phospho标记荧光香豆素,可通过质谱增强结合物的检测†
摘要:荧光香豆素是一类重要的小分子有机荧光团,在不同的成熟和新兴研究领域中普遍存在,其中包括生物化学和化学生物学.目前的工作旨在通过质谱法研究基于香豆素的结合物的可检测性差,同时保持香豆素核心的重要光物理性质.在这种情况下,已经报道了易于功能化的带有-标记的香豆素衍生物的合成,该合成的香豆素衍生物能够通过一步操作对目标分析物或(生物)分子进行双重质量标记和荧光标记.这些香豆素的用途通过荧光底物的制备来说明,该底物有助于鉴定由特异性蛋白水解裂解释放的肽片段.
DOI:10.1039/c6Ob01080F

专利信息

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-10254287-B2
优先权日:2015-07-21
标题 :Protein fluorescent nanoparticles and methods of synthesis thereof
发明人：KUMAR CHALLA VIJAYA; STROMER BOBBI SHANYELLE
权利人:UNIV CONNECTICUT
摘要:Disclosed herein are stable and versatile protein nanoparticles having a range of tunable fluorescent properties. Such nanoparticles may find utility in biological imaging. Methods of synthesis of such nanoparticles are also disclosed.

专利号:US-12195343-B2
优先权日:2019-10-15
标 题 :Synthesis of janus nanomaterials
发明人：WANG WEI
权利人:SAUDI ARABIAN OIL CO
摘要:Synthesizing Janus nanoparticles including forming a lamellar phase having water layers, organic layers, and a surfactant, and reacting chemical precursors in the lamellar phase to form the Janus nanoparticles at interfaces of the water layers with the organic layers.

专利号:US-9012648-B2
优先权日:2012-08-21
标题 :Haptens of risperidone and paliperidone
发明人：HASPESLAGH PIETER RIK; VLIEGEN MAARTEN; HRYHORENKO ERIC; DECORY THOMAS R; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.

专利号:US-9303041-B2
优先权日:2012-08-21
标题 :Haptens of olanzapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

专利号:US-9795685-B2
优先权日:2012-08-21
标 题 :Haptens of aripiprazole
发明人：LIN RONGHUI; SALTER RHYS; DECORY THOMAS R; HRYHORENKO ERIC; REMMERIE BART M; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.