CAS: 389-08-2; 1-Ethyl-7-Methyl-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid

该化合物是一种合成的丙酮抗生素,主要用于治疗克氏菌引起的尿道感染,其行动机制包括抑制细菌DNA甘蓝酶,从而破坏DNA复制和转录.复合物显示有针对易感染菌株的细菌杀菌活动,包括Escherichia coli,Proteus spp.和Klebsiella spp. 氨基苯酸的活动范围相对狭窄,经常被用作微生物研究的第一代五氯酮参考物.关键优势包括该物质对克氏菌病原的特性及其在实验室环境中研究五醇抗机制的效用.抗药性可以迅速发展,限制其临床用途,有利于更广泛的倍感模拟.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号34748-19-1 [N-Ethyl-N-(6-m... | CAS号33331-59-8 ethyl 1-ethyl-1... | CAS号1824-81-3 2-氨基-6-甲基吡啶 | CAS号13250-95-8 2-[[(6-甲基吡啶-2-基... | CAS号13250-96-9 4-羟基-7-甲基-1,8-萘... | CAS号174814-96-1 ethyl 2-(1-ethy... | CAS号10299-49-7 1-ethyl-1,4-dih...

合成工艺路线路线简述

  • 合成目标产物 Nalidixic Acid 主要起始原料 2-Amino-6-Methylpyridine
  • (文献来源)合成步骤主要原料 2-Amino-6-Methylpyridine
乙基1-乙基-7-甲基-4-氧代-1,8-萘啶-3-羧酸酯置于sodium Hydroxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 8.0H,以91%的收率获得产物萘啶酸
参考文献:Synthesis Of Selected Novel Covalently Linked Flavoquinolones
标题:Synthesis Of Selected Novel Covalently Linked Flavoquinolones
摘要:描述了通过混合酸酐法合成新型共价连接的黄酮喹诺酮类化合物,并通过紫外/可见光谱和1H核磁共振光谱数据进行了其光谱学研究.
DOI:10.1055/s-2005-870019

海关参考信息

专利信息


专利号:US-2024197774-A1
优先权日:2021-04-16
标 题:Synthesis of Antimicrobial PVP-coated Bismuth Nanoparticles
发明人:LOPEZ-RIBOT JOSE; VAZQUEZ-MUNOZ ROBERTO
权利人:UNIV TEXAS
摘要:Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

专利号:US-2023002805-A1
优先权日:2021-06-25
标 题 :Use of organic cationic compounds to accelerate nucleic acid hybridization, synthesis, and amplification
发明人:RABBANI ELAZAR; COLEMAN JACK
权利人:ENZO BIOCHEM INC
摘要:The invention provides methods for accelerated synthesis of nucleic acids, and related compositions which involve the use of organic amines in the nucleic acid synthesis reaction mixture. The invention also provides methods for reducing processing steps associated with nucleic acid synthesis. The invention further provides methods for screening compounds that have positive benefits on the synthesis of nucleic acids.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人:CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-9169502-B2
优先权日:2010-06-15
标题 :Method of producing L-lysine using a Corynebacterium glutamicum microorganism
发明人:WITTMANN CHRISTOPH; BECKER JUDITH
权利人:WITTMANN CHRISTOPH; BECKER JUDITH; PAIK KWANG IND CO LTD
摘要:The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人:MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:US-2006194214-A1
优先权日:2005-02-28
标题 :Methods for assembly of high fidelity synthetic polynucleotides
发明人:CHURCH GEORGE; JACOBSON JOSEPH; BAYNES BRIAN M
权利人:CHURCH GEORGE; JACOBSON JOSEPH; BAYNES BRIAN M
摘要:Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or more oligonucleotides using “universalâ€? primers, reduction of the error rate in oligonucleotide and/or polynucleotide products, and sequence optimization and oligonucleotides design.
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主要参考文献


1: Gu B, Cao Y, Pan S, Zhuang L, Yu R, Peng Z, Qian H, Wei Y, Zhao L, Liu G, Tong M. Comparison of the prevalence and changing resistance to nalidixic acid and ciprofloxacin of Shigella between Europe-America and Asia-Africa from 1998 to 2009. Int J Antimicrob Agents. 2012 Jul;40(1):9-17. doi: 10.1016/j.ijantimicag.2012.02.005. Epub 2012 Apr 5. Review. Review.
3: Singh H, Sachdev HP. Nalidixic acid. Indian Pediatr. 1988 Mar;25(3):279-81. Review. Review. Review. Review. Multiple languages. Review. Review. German. Review. Review. Review.

合成参考文献


参考文献:10.3390/ijms12064132
摘要:Janczarek M, Skorupska A. Modulation of rosR expression and exopolysaccharide production in Rhizobium leguminosarum bv. trifolii by phosphate and clover root exudates. Int J Mol Sci. 2011;12(6):4132–55.
参考文献:10.1007/s00248-011-9904-x
摘要:Lo Giudice A, Caruso C, Mangano S, Bruni V, De Domenico M, Michaud L. Marine bacterioplankton diversity and community composition in an antarctic coastal environment. Microb Ecol. 2012 Jan;63(1):210–23. doi: 10.1007/s00248-011-9904-x.
参考文献:10.1007/s10886-011-9991-7
摘要:Abreu IN, Ahnlund M, Moritz T, Albrectsen BR. UHPLC-ESI/TOFMS Determination of Salicylate-like Phenolic Gycosides in Populus tremula Leaves. Journal of Chemical Ecology. 2011 Jul 06;37(8):857. doi: 10.1007/s10886-011-9991-7.
参考文献:10.1080/19440049.2011.587028
摘要:Takeda N, Gotoh M, Matsuoka T. Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011 Sep;28(9):1168–74. doi: 10.1080/19440049.2011.587028.
参考文献:10.3201/eid/1706.101949|10.3201/eid1706.101949
摘要:Su LH, Teng WS, Chen CL, Lee HY, Li HC, Wu TL, Chiu CH. Increasing ceftriaxone resistance in Salmonellae, Taiwan. Emerg Infect Dis. 2011 Jun;17(6):1086–90.
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