2-乙基苯胺 反应生成乙基氯化苄 参考文献:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222 标题:Van Zanten,B.; Nauta,W.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 1211-1222
专利号:US-7189864-B2 优先权日:1990-11-19 标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors 发明人:NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P 权利人:SEARLE & CO 摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
专利号:US-2021332000-A1 优先权日:2014-12-19 标 题:Ethyl Benzyl Quaternary Amines of Amido Amines for Improved Antifungal properties 发明人:DALY THOMAS P 权利人:DALY THOMAS P 摘要:Ethylbenzyl chloride quats (EB quats) and their related salts. The synthesis of EB quats requires minimal capital requirements, produces products in good yields, without difficult to dispose of waste and in a cost-effective manner. The preferred embodiment of the invention is to perform a condensation reaction of a linear or branched, saturated or unsaturated fatty acid, of between 2 and 22 carbons with an amine that has either a primary amine and tertiary amine or a secondary amine and tertiary amine. An example is dimethylaminopropylamine (DMAPA). The amido amine that results from the condensation reaction described is then reacted with ethyl benzyl chloride (EBC) to produce the desired EB quat. Additional processing, such as ion exchange can be performed to eliminate the chlorine or substitute it for another anionic species, organic or inorganic.
专利号:US-2002161234-A1 优先权日:1990-11-19 标 题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
专利号:WO-9323388-A1 优先权日:1992-05-20 标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
专利号:US-2005171366-A1 优先权日:1990-11-19 标 题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
专利号:US-6570027-B2 优先权日:1990-11-19 标题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors