CAS: 241800-98-6; Zoniporide

上下游产品

guanidine hydr°Chloride 5-cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-carboxylic acid chloride guanidine nitrate ethyl 5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxylate

📜Ethyl 2-(Cyclopropanecarbonyl)-3-(Dimethylamino)Acrylate置于sodium Hydroxide,氯化亚砜,三乙胺体系中,用 四氢呋喃,甲醇,乙醇 用作溶剂,化学反应 4.0H,反应生成Zoniporide; Cp 597396; [1-(喹啉-5-基)-5-环丙基-1H-吡唑-4-甲酰基]胍
参考文献:Discovery Of Zoniporide: A Potent And Selective Sodium-hydrogen Exchanger Type 1 (Nhe-1) Inhibitor With High Aqueous Solubility
标题:Discovery Of Zoniporide: A Potent And Selective Sodium-hydrogen Exchanger Type 1 (Nhe-1) Inhibitor With High Aqueous Solubility
摘要:Zoniporide (Cp-597,396) Is A Potent And Selective Inhibitor Of Nhe-1,Which Exhibits High Aqueous Solubility And Acceptable Pharmacokinetics For Intravenous Administration. The Discovery,Synthesis,Activities,And Rat And Dog Pharmacokinetics Of This Compound Are Presented. The Potency And Selectivity Of Zoniporide May Be Due To The Conformation That The Molecule Adopts Due To The Presence Of A Cyclopropyl And A 5-Quinolinyl Substituent On The Central Pyrazole Ring Of The Molecule. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0960-894X(01)00059-2

专利信息

专利号:US-6294538-B1
优先权日:1999-04-01
标 题 :Compounds for treating and preventing diabetic complications
发明人：MYLARI BANAVARA L
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n wherein R is as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.