CAS: 20850-43-5; 5-(Chloromethyl)Benzo[d][1,3]Dioxole

该化合物是属于替代酚类的有机化合物,其特征是其结构,其特征为:一个管状基(源自管道)组(来自管道),其含氯原子,以氯原子替代氢原子.该化合物一般是无色的,不粉黄液体,具有独特的芳香味.Piperonyl氯化物因其反应性而闻名,特别是在核糖类替代反应中,氯原子可以被各种核素取代,经常用作其他化学化合物合成的中间体,包括杀虫剂和药品.此外,由于气味良好,它在红色工业中也具有应用性.安全考虑对于处理管状氯化物十分重要,因为它可能刺激皮肤和眼睛,因此应当采取适当的预防措施以尽量减少接触.

英文名称5-(Chloromethyl)Benzo[d][1,3]Dioxole
中文名称胡椒基氯,5-氯甲基-1,3-苯并二氧杂环戊烯
其它别名3,4-Methylenedioxybenzyl chloride; 5-(Chloromethyl)-1,3-benzodioxole
CAS编号20850-43-5
MFCD编号:MFCD00044328
EINECS号:244-081-2
分子式:C8H7ClO2
分子量:170.59
产品CID: 1060690
产品分类有机原料→分子砌块→芳杂环类化合物→苯并二氧戊环类化合物

相似结构搜索
产品信息参考;;
InChIKey: DWSUJONSJJTODA-UHFFFAOYSA-N
InChI=1S/C7H5ClO2/c8-5-1-2-6-7(3-5)10-4-9-6/h1-3H,4H2…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS05 & GHS07 & GHS09;
注释: Corrosion & Exclamation mark & Environment
危险类别皮肤腐蚀类别1B
皮肤致敏类别1
水生慢性毒性类别2
致癌性类别2
急性毒性类别2(吸入)
急性毒性类别3(经皮)
急性毒性类别3(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Danger(危险)
危险描述H314 |造成严重皮肤灼伤和眼损伤.
H317 |可能引起皮肤过敏反应.
H411 |对水生生物有毒并具有长期持续影响.
H351 |怀疑致癌.
H330 |吸入致命.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级8
UN编号3261.0
危险品标志Xi
风险等级Irritant/Lachrymatory/Moisture Sensitive
包装等级Ⅲ
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

胡椒醇置于三聚氯氰,二甲基亚砜体系中,化学反应 0.33H,以100%的收率获得胡椒基氯
参考文献:中性条件下苄醇的高度化学选择性和快速氯化
标题:中性条件下苄醇的高度化学选择性和快速氯化
摘要:使用二甲亚砜催化的 2,4,6-三氯-1,3,5-三嗪 (Tct) 开发了一种快速,高选择性的氯化方法.反应需要 10 到 40 分钟,产率几乎是定量的.中性反应条件与带有酸不稳定官能团的底物相容.苯甲醇在脂肪醇存在下的竞争性分子内和分子间反应均表明其选择性很高.该方法已成功用于临床上使用的神经药物天麻素的选择性氯化.该程序代表了有机和药物化学中一种有用的新工具.
Doi:10.1055/s-0028-1083243

海关参考信息

2902300000-甲苯
2905110000-甲醇
2907210001-间苯二酚
2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising Î±-D-Gal(1â†’3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of Î±-D-galactopyranosyl-(1â†’3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-10633360-B2
优先权日:2014-12-23
标题 :Efficient process for the synthesis of alkoxy substituted benzaldehydes
发明人：MOHAPATRA Manoj Kumar; BENDAPUDI Ramamohanrao; MENACHERRY Paul Vincent; PAUL VINCENT
权利人:ANTHEA AROMATICS PRIVATE LTD
摘要:The present invention relates to the synthesis of alkoxy substituted benzaldehydes obtained from the corresponding alkoxy substituted benzenes. Alkoxy substituted benzaldehydes are products of broad commercial interest and are used as end products and intermediates in flavor and fragrance applications and pharmaceutical ingredients. For example, 3,4-methylendioxy-benzaldehyde (also known as heliotropin or piperonal) is used widely both as a end product and intermediate for the above mentioned applications. Other examples include 3,4-dimethoxybenzaldehyde, 3,4,5-trimethoxybenzaldehyde and 3,4-ethylenedioxybenzene which are intermediates in the synthesis of active pharmaceutical intermediates.

专利号:US-7919530-B2
优先权日:2002-05-31
标题 :Compounds, compositions, and methods for the treatment of synucleinopathies
发明人：ESPOSITO LUKE A; CUMMINGS JOEL; HUDSON F MICHAEL; SNOW ALAN D
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:US-7601876-B2
优先权日:2002-05-31
标题 :Compounds, compositions and methods for the treatment of amyloid diseases such as systemic AA amyloidosis
发明人：SNOW ALAN D; NGUYEN BETH P; CASTILLO GERARDO M; SANDERS VIRGINIA J; LAKE THOMAS P; LARSEN LESLEY; WEAVERS REX T; LORIMER STEPHEN D; LARSEN DAVID S; COFFEN DAVID L; COFFEN CHARLOTTE
权利人:PROTEOTECH INC
摘要:Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially AÎ² amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

专利号:JP-2018505150-A
优先权日:2014-12-23
标题:An efficient process for the synthesis of alkoxy-substituted benzaldehydes

专利号:CN-107840840-A
优先权日:2016-09-18
标题:Synthesis of an important intermediate of berberine