CAS: 192725-50-1; (S)-3-Methyl-2-(2-Oxotetrahydropyrimidin-1(2H)-yl)Butanoic Acid

相似化合物

103365-69-1 5988-19-2 155-54-4

上下游产品

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(S)-3-Methyl-2-(2-Oxo-Tetrahydro-Pyrimidin-1-yl)-Butyric Acid Methyl Ester置于lithium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应 14.0H,以75%的收率获得(2S)-(1-四氢嘧啶-2-酮)-3-甲基丁酸
参考文献:Retroviral Protease Inhibiting Compounds
标题:Retroviral Protease Inhibiting Compounds
摘要:披露了一种包含公式(II)取代基的化合物,作为一种hiv蛋白酶抑制剂.还披露了用于制造此类化合物的中间体以及制造此类中间体的过程.

专利信息

专利号:US-2005222184-A1
优先权日:2002-05-30
标题 :Process for preparing (s)-tetrahydro-a-(1-methylethyl)-2-oxo-1(2h)-pyrimidineacetic acid
发明人：BERTOLINI GIORGIO; FELICIOTTI LUCA; FRIGERIO MARCO; LOSA MASSIMO
权利人:BERTOLINI GIORGIO; FELICIOTTI LUCA; FRIGERIO MARCO; LOSA MASSIMO
摘要:A process for preparing (S)-tetrahydro-a-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetic acid, an intermediate that is useful in the synthesis of HIV protease inhibitors such as, for example, those described in U.S. Pat. No. 5,914,332, is described. The process under consideration comprises the following steps:—L-valine is reacted with acrylonitrile;—the N-(2-cyanoethyl)-L-valine thus obtained is isolated and then reacted with an alkyl chloroformate;—the N-(2-cyanoethyl)-N-(alkoxycarbonyl)-L-valine thus obtained is hydro-genated in the presence of a hydrogenation catalyst, preferably rhodium;—the N-(3-aminopropyl)-N-(methoxycarbonyl)-L-valine thus obtained is cyclized to give the desired compound.

专利号:WO-2006090264-A1
优先权日:2005-02-28
标 题 :A process for the synthesis of 2-amino-5-protected amino-3-hydroxy-1, 6-diphenylhexane or a salt thereof - an intermediate for antiviral drugs
发明人：BOSE PROSENJIT; BISWAS SUJOY; RATHORE RAMENDRA SINGH; SACHDEVA YOGINDER PAL; KUMAR YATENDRA
权利人:RANBAXY LAB LTD; BOSE PROSENJIT; BISWAS SUJOY; RATHORE RAMENDRA SINGH; SACHDEVA YOGINDER PAL; KUMAR YATENDRA
摘要:The present invention relates to an improved process for preparing 2-amino-5-protected-amino-3-hydroxy-1,6-diphenylhexane compounds or acid addition salts thereof, which can be useful intermediates for preparing compounds with antiviral activity. The present invention further provides a process for preparing HIV protease inhibitors, lopinavir and ritonavir.