专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:WO-2025019598-A1 优先权日:2023-07-20 标 题:Positive allosteric modulator of the metabotropic glutamate receptor subtype 2 receptor, synthesis and solid forms thereof 发明人:COSFORD NICHOLAS DAVID PETER; SHEFFLER DOUGLAS J 权利人:SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST 摘要:Described herein are solid forms of sodium 4-chloro-3'-(((2-cyclopentyl-1-oxoisoindolin-5-yl)oxy)methyl)-[1,1'-biphenyl]-3-carboxylate and its pharmaceutical composition for the treatment of disease.
专利号:US-7902394-B2 优先权日:2006-12-18 标题:Calcilytic compounds 发明人:MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT 权利人:GLAXOSMITHKLINE LLC 摘要:Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.
专利号:CN-110078613-B 优先权日:2019-05-31 标 题 :Synthesis method of 2-halogen-5-iodobenzoic acid
专利号:CN-116332882-A 优先权日:2023-03-21 标题:Synthesis process of key intermediate of englitz
专利号:CN-116332882-B 优先权日:2023-03-21 标 题 :Synthesis process of key intermediate of englitz
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025). 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2025).