CAS: 1637771-14-2; (2-Cyclopropyl-5-(3,5-Dimethylisoxazol-4-yl)-1H-Benzo[d]Imidazol-7-yl)Di(Pyridin-2-yl)Methanol

专利信息

专利号:US-2018179191-A1
优先权日:2016-11-22
标题 :Synthesis of a compound that modulates the activity of bromodomain-containing proteins
发明人：SHEN JINYU; ST JULES MUSTAPHA; SPERANDIO DAVID; MOHAN SANKAR
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n n n n n n n n n n or a salt or co-crystal thereof, that modulates the activity of bromodomain-containing proteins. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

专利号:WO-2018097976-A1
优先权日:2016-11-22
标 题 :Synthesis of a compound that modulates the activity of bromodomain-containing proteins

专利号:TW-201823237-A
优先权日:2016-11-22
标题:Synthesis of compounds that regulate the activity of proteins containing bromine domains (BROMODOMAIN)

专利号:US-12103929-B2
优先权日:2018-06-25
标题:Tricyclic compounds
发明人：FANG HAIQUAN; CHEN MINGMING; YANG GUIQUN; DU YUELEI; WANG YANPING; WU TONG; LI QINGLONG; ZHANG LEI; HU SHAOJING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.