📜4-氨基-3-羟基苯甲酸置于原甲酸三甲酯体系中,用89%的收率获得1,3-苯并恶唑-6-羧酸 参考文献:Quinuclidine-Substituted Hetero-Bicyclic Aromatic Compounds For The Treatment Of Disease 标题:Quinuclidine-Substituted Hetero-Bicyclic Aromatic Compounds For The Treatment Of Disease 摘要:这项发明提供了formula I的化合物: 其中w0是一个双环基团,是 这些化合物可以是药物盐或组合物的形式,可以是纯对映体形式或混合物,对治疗已知涉及α7的疾病或症状有用.
专利号:SU-1456426-A1 优先权日:1987-07-03 标 题:Derivatives of dibenzoxazols as monomers for synthesis of soluble heat-resistant polybenzimidazolbenzoxasols
专利号:US-11299484-B2 优先权日:2018-10-10 标 题 :Inhibiting fatty acid synthase (FASN) 发明人:MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.
参考文献:10.1007/s12274-023-5581-6 摘要:Huang T, Sun X, Qi Y, Yang X, Fan L, Chen M, Yue Y, Ge H, Li Y, Nie G, Min H, Sun X. Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity. Nano Res. 2023 Mar 18;16(12):13250–8. doi: 10.1007/s12274-023-5581-6. 参考文献:10.1007/s11426-023-1841-8 摘要:Gao Y, Zhao H, Zhao J, Ma S, Si X, Liu L, Qiao R, Song W, Chen X. Polymer-based synthetic oncolytic virus-like nanoparticles for cancer immunotherapy. Sci. China Chem. 2023 Nov 21;66(12):3576–86. doi: 10.1007/s11426-023-1841-8.