CAS: 129046-87-3; (S)-4-((9H-Fluoren-9-yl)Methoxy)-3-((Tert-Butoxycarbonyl)Amino)-4-Oxobutanoic Acid

相似化合物

129460-09-9 134098-70-7 117014-32-1

上下游产品

9-Fluorenylmethanol N-tert-butyloxycarbonylaspartic acid anhydride tert-butyl dicarbonatedi-tert-butyl dicarbonate B°C-Asp-OH2-(tert-butoxycarbonyl)-N4-[2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl-(1-4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine fluorenylmethyl esterN2-(tert-butoxycarbonyl)-N4-[2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranosyl-(1-4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranosyl]-L-asparagine fluorenylmethyl ester

📜二碳酸二叔丁酯置于n,N-二甲氨基-2-氯丙烷盐酸盐,Sodium Carbonate,N,N-二异丙基乙胺体系中,用 四氢呋喃,水 用作溶剂,化学反应 52.0H,反应生成N-叔丁氧羰基-L-天冬氨酸 1-(9H-芴-9-基甲基)酯
参考文献:An Unexpected Product From Attempted Reductive Etherification Of A Silyl Alcohol With An Aldehyde
标题:An Unexpected Product From Attempted Reductive Etherification Of A Silyl Alcohol With An Aldehyde
摘要:Reductive Etherification,Using Bibr3/et3Sih,Between Two Modified Amino Acids,One With A Silyl Alcohol Side Chain And One With An Aldehyde Side Chain,Gave,Not The Desired Bis-Amino Acid,But A Tetrahydrooxazine,In Good Yield. (C) 2007 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2007.03.163

专利信息

专利号:US-6008058-A
优先权日:1993-06-18
标 题:Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
发明人：SPATOLA ARNO F; DARLAK KRZYSZTOF; WEN JAMES JUN; ROMANOVSKIS PETERIS
权利人:UNIV LOUISVILLE RES FOUND
摘要:A method of preparing cyclic peptide mixtures via side chain or backbone and solid phase synthesis. The cyclic peptide mixtures form libraries that are useful for screening purposes featuring the attachment of an amino acid to a solid support through its side chain or backbone in order to mimic solution cyclization procedures with linear peptides. In the preferred embodiment, Boc chemistry is used for peptide synthesis, wherein the initial attachment of a trifunctional amino acid is by the aspartyl side chain (with OFm for alpha-carboxyl protection). Cyclization is performed using uronium reagents with racemization suppressant, and a strong acid (HF) is used for deprotection and cleavage. The strategy has been used for the preparation of a series of cyclic peptide mixtures. The procedure is expandable to include at least twenty different amino acids at each position (except the resin linked position where most attachments are by Asp, Lys, Glu, or Orn). The cyclic peptide mixtures vary in ring size from about four to about twelve residues.