CAS: 1012341-50-2; (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((Tert-Butoxycarbonyl)Amino)-2-Methylpentanoic Acid

上下游产品

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydr°Chloride tert-butyl dicarbonatedi-tert-butyl dicarbonate (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydr°Chloride (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydr°Chloride ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate (2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid triethylammonium salt

在 双氧水,Lithium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 3.5H,以90%的收率获得(2R,4S)-5-(联苯-4-基)-4-[(叔丁氧基羰基)氨基]-2-甲基戊酸
参考文献:Ahu-377中间体的制备方法及其中间体和中 间体的制备方法
标题:Ahu-377中间体的制备方法及其中间体和中 间体的制备方法
摘要:本发明涉及药物化学合成领域,具体涉及一种ahu‑377中间体的制备方法及其中间体和中间体的制备方法.式(ⅰ)所示ahu‑377中间体的制备方法,所述的方法包括将式(ⅱ)化合物与式(ⅲ)所示的化合物通过取代反应后再经过水解制备式(ⅰ)所示的ahu‑377的中间体,所述的水解反应是在双氧水和水合氢氧化锂的存在下进行:本发明的另一目的是提供一种新的化合物,结构如式(ⅱ)所示:本发明的新路线中,由于使用式(ⅱ)化合物和式(ⅲ)所示的化合物反应制备获得新的式(Iv)所示化合物,选择性非常好,反应过程中生成的非对映异构体的量很少,这些极少量非对映异构体也只需经过简单的后处理即可除去.

专利信息

专利号:US-10851059-B2
优先权日:2016-08-17
标题:Processes and intermediates for NEP inhibitor synthesis
发明人：KLEINBECK-RINIKER FLORIAN KARL; MAFLI IVES; MARTIN BENJAMIN; PENN GERHARD; SEDELMEIER GOTTFRIED; SEDELMEIER JOERG; VENTURONI FRANCESCO
权利人:NOVARTIS AG
摘要:The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

专利号:CN-118109528-A
优先权日:2024-04-10
标题 :A method for biocatalytic synthesis of sacubitril intermediate (2R, 4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylvaleric acid

专利号:CN-118516422-A
优先权日:2024-04-10
标 题:A method for biocatalytic synthesis of sacubitril intermediates

专利号:US-11161803-B2
优先权日:2017-04-28
标题:Ammonium carboxylate compound, crystalline form, amorphous form and preparation method thereof
发明人：ZHANG BO; DING XIAOHUA; DAI DONGCHENG; LEI SIJUN; LIU XUEMING; DUAN PANPAN; CHEN YONGKAI; WANG CHAODONG
权利人:WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD
摘要:The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

专利号:CN-118291560-A
优先权日:2024-04-10
标 题:Synthesis method of sabatier intermediate (2R, 4S) -5- ([ 1,1' -biphenyl ] -4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methyl ethyl valerate