CAS: 869886-90-8; 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid

英文名称4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid
中文名称4-(5-氯-2-(异丙基氨基)吡啶-4-基)-1H-吡咯-2-羧酸
IUPAC名称4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
其它别名4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid; 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid 4-(5-Chloro-2-Isopropylaminopyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid; 1H-Pyrrole-2-Carboxylic Acid, 4-[5-Chloro-2-[(1-Methylethyl)Amino]-4-Pyridinyl]-; 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Car; 4-{5-Chloro-2-[(Propan-2-yl)Amino]Pyridin-4-Yl}-1H-Pyrrole-2-Carboxylic Acid
CAS编号869886-90-8
MFCD编号:MFCD26394053
分子式:C13H14ClN3O2分子量:279.73
产品CID: 1873934
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: NCBIFXNQFURYON-UHFFFAOYSA-N
InChI=1S/C13H14ClN3O2/c1-7(2)17-12-4-9(10(14)6-16-12)8-3-11(13(18)19)15-5-8/h3-7,15H,1-2H3,(H,16,17)(H,18,19)
计算化学: 氢键受体数3.0氢键供体数3可旋转键数4

相似化合物

197774-71-3 197774-66-6 197775-26-1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(2,4,6-trimethylbenzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 5-chloro-2-fluoro-4-iodopyridine 5-chloro-4-iodo-N-isopropylpyridin-2-amine 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylicacid[1-(3-chlorophenyl)-2-hydroxyethyl]amide hydr°Chloride

合成工艺路线路线简述

合成目标产物 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1H-Pyrrole-2-Carboxylic Acid 主要起始原料 Methyl 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1-Tosyl-1H-Pyrrole-2-Carboxylate
(文献来源)合成步骤主要原料 Methyl 4-(5-Chloro-2-(Isopropylamino)Pyridin-4-yl)-1-Tosyl-1H-Pyrrole-2-Carboxylate

📜2,5-二氯吡啶置于四(三苯基膦)钯甲醇,Sodium Hydroxide,乙酰溴,硫酸,水,双氧水,硝酸,乙酸酐,Sodium Carbonate,三氯化磷体系中,用二氯甲烷,水,苯作为反应溶剂,化学反应 87.84H,反应生成 4-(5-氯-2-(异丙基氨基)吡啶-4-基)-1H-吡咯-2-羧酸
参考文献: Pyrrole Compounds As Inhibitors Of Erk Protein Kinase,Synthesis Thereof And Intermediates Thereto[fr] Composes Pyrroles Utilises En Tant Qu'Inhibiteurs De Proteines Kinases Erk,Leur Synthese,Et Intermediaires Correspondants
标题: Pyrrole Compounds As Inhibitors Of Erk Protein Kinase,Synthesis Thereof And Intermediates Thereto[fr] Composes Pyrroles Utilises En Tant Qu'Inhibiteurs De Proteines Kinases Erk,Leur Synthese,Et Intermediaires Correspondants
摘要:本发明涉及一种用于蛋白激酶抑制剂的化合物.该发明还提供了包含所述化合物的药学上可接受的组合物,并提供了在治疗各种疾病,病况或障碍中使用这些组合物的方法.