CAS: 863127-77-9; N-(2-Chloro-6-Methylphenyl)-2-((6-(4-(2-Hydroxyethyl)Piperazin-1-yl)-2-Methylpyrimidin-4-yl)Amino)Thiazole-5-Carboxamide Hydrate

上下游产品

1-(2-hydroxyethyl)piperazine 2-(6-chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide dasatanib N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamidedasatanib

达沙替尼置于水体系中,用 甲醇 作为反应溶剂,以21 G的收率获得产物一水达沙替尼
参考文献:达沙替尼一水合物的新晶形及其制备方法和 药物组合物
标题:达沙替尼一水合物的新晶形及其制备方法和 药物组合物
摘要:本发明涉及药物技术领域,具体涉及达沙替尼一水合物的晶形,制备方法及其药物组合物.本发明达沙替尼一水合物的晶形在光照,高温,高湿及加速实验条件下都十分稳定,其药物组合物溶出度好,可在高温条件下稳定.另外,本发明制备方法与现有技术相比具有操作简便,质量可控的优点.尤其重要的一点,制剂过程中本发明晶型更稳定.

专利信息

专利号:US-12390420-B1
优先权日:2024-10-22
标题 :Compositions for targeted delivery of therapeutic agents and methods for the synthesis and use thereof
发明人：EGUCHI MASAKATSU
权利人:BRYET US INC
摘要:The present disclosure provides compositions and methods for delivering therapeutic agents to particular tissues or cells in a subject. The composition disclosed herein combines unique properties of porous micro- or nano-particles with host-guest chemistry provided by functionalized silicon particle, offering a versatile approach to addressing the challenges associated with delivering therapeutic agents to target tissues or sites within the body. The present disclosure also provides a method for synthesizing a composition capable of delivering therapeutic agents to particular tissues or cells in a subject.

专利号:WO-2024254278-A9
优先权日:2023-06-08
标题 :Ophthalmic films
发明人：BANERJEE AMRITA; MITRAGOTRI SAMIR; LEVINSON DOUGLAS
权利人:FOUNT BIO INC
摘要:The present application describes the synthesis, formulation and uses of systems comprising conjugates or materials prepared therefrom, capable of retaining systems on the ocular surface.

专利号:CN-102827156-A
优先权日:2012-09-11
标 题:A new industrial synthesis method of dasatinib