CAS: 825-41-2; 3-Chloro-4-Nitroaniline

该化合物是一种卤化硝酸化合物,其分子式为C6H5ClN2O2.它是黄色至橙色晶状固体,主要用作染料,颜料和药物合成的中间体.芳香环上存在氯和硝基替代物,这增加了其反应性,使其对电益替代和混合反应具有价值.在受控制条件下,它的高纯度和稳定性确保工业应用的一贯性能.该化合物还因其功能组而被用于农业化学研究,有助于开发活性成分.适当的处理由于其潜在毒性和刺激性,是至关重要的.

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上下游产品

3-Chloroacetanilide 3-chloro-4-nitroacetanilide 3-chloro-aniline 2-Chloronitrobenzene 1-chloro-5-cyano-2-nitrobenzene 2,3,6-trichloro-4-nitro-aniline 2-chloro-4-iodo-1-nitro-benzene 5-amino-2-nitrobenzonitrile

合成工艺路线路线简述

    📜硝基氯苯置于potassium Tert-Butylate,Ammonium Pyrrolidinedithiocarbamate体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.33H,以72%的收率获得产物3-氯-4-硝基苯胺
    参考文献:Nitroarylamines Via The Vicarious Nucleophilic Substitution Of Hydrogen: Amination,Alkylamination,And Arylamination Of Nitroarenes With Sulfenamides
    标题:Nitroarylamines Via The Vicarious Nucleophilic Substitution Of Hydrogen: Amination,Alkylamination,And Arylamination Of Nitroarenes With Sulfenamides
    摘要:A New Reaction Of Sulfenamides With Electrophilic Arenes Under Basic Conditions Is Described. The Sigma Adducts Formed From Nitroarenes And The Anions Of Sulfenamides Undergo Elimination Of Thiol To Produce The Corresponding O-And/or P-Nitroanilines. This Reaction Is Analogous To The Known Alkylation And Hydroxylation Of Nitroarenes Via The Vicarious Nucleophilic Substitution Of Hydrogen (Vns). The Reaction Gives Access To A Wide Range Of Substituted Nitroanilines,Nitronaphthylamines,And Aminoheterocycles. By Means Of The Reaction With N-Alkryl-And N-Arylsulfenamides,It Is Possible To Obtain N-Alkylnitroanilines And Nitrodiarylamines. By Varying The Structure Of Sulfenamide And The Reaction Conditions,Particularly The Nature And Concentration Of The Base,It Is Possible To Control The Orientation Of Amination.
    DOI:10.1021/jo970582B

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    专利信息


    专利号:EP-0332033-A2
    优先权日:1988-03-11
    标 题:N-cyclopropyl anilines and their use in processes for the synthesis of 1-cyclopropyl-quinolone-carboxylic acids and their derivatives
    发明人：SCHRIEWER MICHAEL DR; PETERSEN UWE DR; GROHE KLAUS DR; KREBS ANDREAS DR
    权利人:BAYER AG
    摘要:N-Cyclopropylanilines of the formula (IV) in which R<1>, X<1>, X<2>, X<3>, A, Z and R<2> have the meaning given in the description, which are suitable for the preparation of 4-quinolone- 3-carboxylic acids, and processes for the preparation of quinolone- carboxylic acid derivatives using N-cyclopropylanilines.

    专利号:CN-1045433-C
    优先权日:1994-07-03
    标 题:Synthesis of colour negative yellow double-equivalent colour coupler

    专利号:CN-1114647-A
    优先权日:1994-07-03
    标 题 :Synthesis of colour negative yellow double-equivalent colour coupler

    专利号:CN-117645547-A
    优先权日:2023-12-08
    标 题:A kind of synthesis method of 2-chloro-1,4-phenylenediamine

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    合成参考文献


    摘要:J.P. Idoux and C.K. Hancock. J. Org. Chem. 33, 3498 (1968).
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