CAS: 79868-79-4; (R)-2-Amino-1,1,2-Triphenylethanol

该化合物是有机化合物,其特征是其手性结构,其特点是一个氨基氨基基化合物组和一个附属于碳中心,同时也与三个苯基组捆绑在一起的羟基化合物,该化合物一般是白色至非白色固体,以其在不对称合成中的潜在应用和各种化学反应中作为手性辅助工具而著称,氨基和羟基功能组的存在有助于其进行氢结合的能力,影响其溶解性和再活性.三苯基混合物提供了大量的静态成分,可影响该化合物与其他分子的相互作用,使其在催化和制药化学中有用.此外,该分子的性能使得有可能进行对等分化,这对于药化学中对应性纯化合物的发展至关重要.总体来说,(R)-2-氨基1-1-1-2-苯基乙基乙醇是学术研究和工业应用中的宝贵化合物.

结构式图片

物理性质

MSDS等安全信息

上下游产品

benzophenone benzylamine hippuric acid-(2-hydroxy-1,2,2-triphenyl-ethylamide) N-benzylidene-2-methoxy-1-phenylethanamine4,5,5-triphenyl-oxazolidin-2-one hippuric acid-(2-hydroxy-1,2,2-triphenyl-ethylamide) benzophenone benzylamine

合成工艺路线路线简述

  • 2243141-47-9 = 79868-79-4
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol; 0 °C; 4 H,Rt
    标题:Addition Of The Lithium Anion Of Diphenylmethanol Methyl/methoxymethyl Ether To Nonracemic Sulfinimines: Two-Step Asymmetric Synthesis Of Diphenylprolinol Methyl Ether And Chiral (Diphenylmethoxymethyl)Amines
    作者:Reddy,Arava Amaranadha; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2018 卷标:83(18) 页码:10776-10785]

    1395342-04-7 = 79868-79-4
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium,Palladium Dihydroxide Solvents: Acetic Acid,Methanol,Dichloromethane,Water; Overnight,30 °C1.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Titanium-Mediated Cross-Coupling Reactions Of Imines With Ketones Or Aldehydes: An Efficient Route For The Synthesis Of 1,2-Amino Alcohols
    作者:Fan,Guoqin; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(38) 页码:5084-5087]

    19883-41-1 = 79868-79-4
    反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether; 1 H,Reflux; Reflux -> Rt; Rt -> 0 °C1.2 2 H,0 °C; Overnight,Rt1.3 Reagents: Water; Cooled1.4 Reagents: Hydrochloric Acid Solvents: Water; Cooled; 1 H,Cooled1.5 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Rt
    标题:Structure Determination Of Bisacetylenic Oxylipins In Carrots (Daucus Carota L.) And Enantioselective Synthesis Of Falcarindiol
    作者:Schmiech,Ludger; Et Al
    参考文献:Journal Of Agricultural And Food Chemistry 日期:2009 卷标:57(22) 页码:11030-11040]

    119-61-9 = 79868-79-4
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane,Hexamethylphosphoramide1.2 Solvents: Tetrahydrofuran1.3 Reagents: Acetic Acid Solvents: Tetrahydrofuran2.1 Reagents: Hydroxylammonium Acetate Solvents: Ethanol
    标题:Asymmetric Syntheses. Vi. Asymmetric Aldol Reaction Of D-Camphor Imine Derived From Benzylamine
    作者:Jiang,Yaozhong; Et Al
    参考文献:Synthetic Communications 日期:1988 卷标:18(11) 页码:1291-8]

    223930-75-4 + 186249-74-1 = 79868-79-4
    反应条件:1.1 Reagents: Butyllithium,N,N,N′,N′-Tetramethylethylenediamine Solvents: Tetrahydrofuran,Hexane; -40 °C; 0.5 H,-40 °C1.2 Solvents: Tetrahydrofuran; -78 °C; 1 H,-78 °C1.3 Reagents: Ammonium Chloride Solvents: Water; Rt2.1 Reagents: Hydrochloric Acid Solvents: Methanol; 0 °C; 4 H,Rt
    标题:Addition Of The Lithium Anion Of Diphenylmethanol Methyl/methoxymethyl Ether To Nonracemic Sulfinimines: Two-Step Asymmetric Synthesis Of Diphenylprolinol Methyl Ether And Chiral (Diphenylmethoxymethyl)Amines
    作者:Reddy,Arava Amaranadha; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2018 卷标:83(18) 页码:10776-10785]

    91298-74-7 + 100-52-7 = 79868-79-4
    反应条件:1.1 Reagents: Sulfuric Acid Magnesium Salt (1:1) Solvents: Dichloromethane; Overnight,Rt2.1 Reagents: Titanium Isopropoxide,Cyclopentylmagnesium Chloride Solvents: Diethyl Ether; -30 °C; 3 H,-30 °C2.2 -30 °C; -30 °C -> Rt; 2 H,Rt2.3 Reagents: Sodium Bicarbonate Solvents: Water; 1 H,Rt3.1 Reagents: Hydrogen Catalysts: Palladium,Palladium Dihydroxide Solvents: Acetic Acid,Methanol,Dichloromethane,Water; Overnight,30 °C3.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Titanium-Mediated Cross-Coupling Reactions Of Imines With Ketones Or Aldehydes: An Efficient Route For The Synthesis Of 1,2-Amino Alcohols
    作者:Fan,Guoqin; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(38) 页码:5084-5087]

    20989-17-7 = 79868-79-4
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; Rt; 2 H,Rt1.2 1 H,Rt; Rt -> Reflux; 3 H,Reflux2.1 Reagents: Sulfuric Acid Magnesium Salt (1:1) Solvents: Dichloromethane; Overnight,Rt3.1 Reagents: Titanium Isopropoxide,Cyclopentylmagnesium Chloride Solvents: Diethyl Ether; -30 °C; 3 H,-30 °C3.2 -30 °C; -30 °C -> Rt; 2 H,Rt3.3 Reagents: Sodium Bicarbonate Solvents: Water; 1 H,Rt4.1 Reagents: Hydrogen Catalysts: Palladium,Palladium Dihydroxide Solvents: Acetic Acid,Methanol,Dichloromethane,Water; Overnight,30 °C4.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Titanium-Mediated Cross-Coupling Reactions Of Imines With Ketones Or Aldehydes: An Efficient Route For The Synthesis Of 1,2-Amino Alcohols
    作者:Fan,Guoqin; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(38) 页码:5084-5087]

    865700-89-6 = 79868-79-4
    反应条件:1.1 Reagents: Methanesulfonic Acid Catalysts: Palladium Solvents: Water; Overnight,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10
    标题:Synthesis Of Heavily Substituted 1,2-Amino Alcohols In Enantiomerically Pure Form
    作者:Garcia-Delgado,Noemi; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7426-7428]

    19883-41-1 = 79868-79-4
    反应条件:1.1 Solvents: Diethyl Ether; 30 Min,0 °C; 30 Min,0 °C; 20 H,0 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 0 °C; 1 H,0 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Rt
    标题:Synthesis And Structural Analysis Of Palladium(Ii) Complexes Containing Neutral Or Anionic C2-Symmetric Bis(Oxazoline) Ligands: Effects Of Substituents In The 5-Position
    作者:Tsutsumi,Ken; Et Al
    参考文献:Acs Omega 日期:2017 卷标:2(7) 页码:3886-3900]

    19883-41-1 = 79868-79-4
    反应条件:1.1 Solvents: Diethyl Ether; 0 °C
    标题:(R)-B-Methyl-4,5,5-Triphenyl-1,3,2-Oxazaborolidine
    作者:Garcia,Jordi
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2002 卷标:1 页码:1-3]

    19883-41-1 = 79868-79-4
    反应条件:1.1 Solvents: Diethyl Ether; 10 Min,Cooled; 3 H,Reflux1.2 Reagents: Water; Cooled
    标题:New Phenylglycine-Derived Primary Amine Organocatalysts For The Preparation Of Optically Active Warfarin
    作者:Kristensen,Tor E.; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2009 卷标:(30) 页码:5185-5191]

    24461-61-8 = 79868-79-4 [标题:Reaction Conditions
    标题:Product Subclass 8: Boroxanes
    作者:Periasamy,M.; Et Al
    参考文献:Science Of Synthesis 日期:2004 卷标:6 页码:301-320]

    = 79868-79-4
    反应条件:1.1 Reagents: Hydroxylammonium Acetate Solvents: Ethanol
    标题:Asymmetric Syntheses. Vi. Asymmetric Aldol Reaction Of D-Camphor Imine Derived From Benzylamine
    作者:Jiang,Yaozhong; Et Al
    参考文献:Synthetic Communications 日期:1988 卷标:18(11) 页码:1291-8]

    157556-88-2 = 79868-79-4
    反应条件:1.1 Reagents: Lithium Perchlorate; 24 H,1.5 Bar,120 °C2.1 Reagents: Methanesulfonic Acid Catalysts: Palladium Solvents: Water; Overnight,Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10
    标题:Synthesis Of Heavily Substituted 1,2-Amino Alcohols In Enantiomerically Pure Form
    作者:Garcia-Delgado,Noemi; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(18) 页码:7426-7428]

    119-61-9 + 153924-61-9 = 79868-79-4
    反应条件:1.1 Reagents: Titanium Isopropoxide,Cyclopentylmagnesium Chloride Solvents: Diethyl Ether; -30 °C; 3 H,-30 °C1.2 -30 °C; -30 °C -> Rt; 2 H,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; 1 H,Rt2.1 Reagents: Hydrogen Catalysts: Palladium,Palladium Dihydroxide Solvents: Acetic Acid,Methanol,Dichloromethane,Water; Overnight,30 °C2.2 Reagents: Sodium Hydroxide Solvents: Water
    标题:Titanium-Mediated Cross-Coupling Reactions Of Imines With Ketones Or Aldehydes: An Efficient Route For The Synthesis Of 1,2-Amino Alcohols
    作者:Fan,Guoqin; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(38) 页码:5084-5087]

    875-74-1 = 79868-79-4
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Methanol; 20 Min,Cooled; 46 H,Rt2.1 Solvents: Diethyl Ether; 10 Min,Cooled; 3 H,Reflux2.2 Reagents: Water; Cooled
    标题:New Phenylglycine-Derived Primary Amine Organocatalysts For The Preparation Of Optically Active Warfarin
    作者:Kristensen,Tor E.; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2009 卷标:(30) 页码:5185-5191

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合成参考文献

合成方法参考DOI号:10.1021/acs.j°C.8b01381
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