CAS: 78920-10-2; 5-Hydroxy-4-Propylfuran-2(5H)-One

相似化合物

40834-42-2 1575-49-1 3008246-34-9

正戊醛置于吗啉,盐酸体系中,用 正庚烷,水 作为反应溶剂,化学反应 23.0H,以90.8%的收率获得产物5-羟基-4-正丙基-2-呋喃酮
参考文献: Process For Preparing 2-Oxo-1-Pyrrolidine Derivatives[fr] Methode De Preparation De Derives De 2-Oxo-1-Pyrrolidine
标题: Process For Preparing 2-Oxo-1-Pyrrolidine Derivatives[fr] Methode De Preparation De Derives De 2-Oxo-1-Pyrrolidine
摘要:本发明涉及一种制备通式(i)中取代基如规范中所定义的2-氧代-1-吡咯烷衍生物的新方法.

专利信息

专利号:US-2022064111-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof
发明人：ROY SARABINDU; GHOSH ANGSHUMAN; KUBEER RAMESH DHONDI; PRASAD MUTYALA V V VARA; PAUL GOPAL; GARAI ABHISHEK; CHAKRABORTY SOURAV; HALDAR ANIMESH; YADAW AJAY KUMAR; ROY SUBHO
权利人:CLININVENT RES PVT LTD
摘要:The present invention relates to an improved and economical process for enantioselective synthesis and purification of a novel key intermediate of Brivaracetam. Further, the present invention also relates to a process for the preparation of a chirally pure Brivaracetam of formula I utilizing the said intermediate.

专利号:US-11884623-B2
优先权日:2022-05-23
标题:Process for the preparation of (R)-4-propyl pyrrolidine-2-one, a key intermediate for synthesis of brivaracetam
发明人：DIVI MURALI KRISHNA PRASAD; BOLNENI NAGESWARA RAO; BANDARUPALLI LEELA MAHESWARA RAO
权利人:DIVIS LABORATORIES LTD
摘要:A process for the preparation of (R)-4-propyl-pyrrolidine-2-one, is provided which includes enzymatic conversion of dimethyl 3-propyl pentanedioate selectively into (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid using Novozyme's Promea® enzyme, amidation of (S)-3-(2-methoxy-2-oxoethyl) hexanoic acid, followed by ester hydrolysis to obtain (S)-3-(2-amino-2-oxoethyl) hexanoic acid having high chiral purity >99% and converting the amide to amine by Hofmann rearrangement and cyclization resulting in (R)-4-propyl-pyrrolidine-2-one. It is further converted to Brivaracetam by N-alkylation with 2-bromobutyric acid, esterification followed by enzymatic resolution.

专利号:US-8716520-B2
优先权日:2010-01-15
标题:Method of resolution of (RS)- 1,1′-BI-2-naphthol for obtaining enantiomeric pure I.E. (S)-(−)-1,1′-BI-2-naphthol and/or (R)-(+)-1,1′-BI-2-naphthol via co-crystal formation with optically active derivatives of γ-amino acids
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; MITRA RANGAN
权利人:ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; MITRA RANGAN; LUPIN LTD
摘要:Novel method for synthesis of optically pure (S)-(−)-1,1′-bi-2-naphthol and/or (R)-(+)-1,1′-bi-2-naphthol via resolution of racemic (RS)-1,1′-bi-2-naphthol through formation of co-crystal with optically active derivatives of γ-amino acids.

专利号:US-11518741-B2
优先权日:2018-06-20
标题 :Brivaracetam intermediate, preparation method therefor, and preparation method for brivaracetam
发明人：YANG HANRONG; QI YANTAO; LI TAO; WANG BO
权利人:SHANGHAI PUYI CHEMICAL CO LTD
摘要:The present invention relates to a brivaracetam intermediate, a preparation method therefor, and a preparation method for brivaracetam. The steps of the method for preparing brivaracetam described in the present invention are short and the raw materials are cheap, moreover, the method is simple and highly effective without requiring isomer separation by means of column chromatography or asymmetric synthesis, being suitable for industrial large-scale production. In addition, disclosed by the present invention is a compound as shown in formula (II), which may be used for the synthesis of brivaracetam.

专利号:WO-2020143674-A1
优先权日:2019-01-09
标 题:Compounds and their use in the synthesis of brivaracetam apis

专利号:WO-2020148787-A1
优先权日:2019-01-17
标 题:Enantioselective synthesis of brivaracetam and intermediates thereof