专利号:SA-109300715-B1 优先权日:2008-12-01 标 题 :Synthesis of (R)-3-((E)-2-(pyrrolidine-3-yl)-phenyl)-5-(tetrahydropyrane-4-yloxy)pyridine and forms new salts thereof
专利号:US-8633227-B2 优先权日:2008-12-01 标 题 :Synthesis and novel salt forms of (R)-3-((E)-pyrrolidin-3-yl)vinyl)-5-tetrahydropyran-4-yloxy)pyridine 发明人:AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI 权利人:AKIREDDY SRINIVASA RAO; BREINING SCOTT R; CUTHBERTSON TIMOTHY J; DULL GARY MAURICE; GATTO GREGORY J; GENUS JOHN; HAMMOND PHILIP S; MITCHENER JR JOESPH PIKE; MUNOZ JULIO A; OTTEN PIETER ALBERT; YOHANNES DANIEL; FEDOROV NIKOLAI; TARGACEPT INC 摘要:The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.
专利号:TW-202412791-A 优先权日:2022-08-16 标 题 :Synthesis of substituted tetracyclic carboxylic acids and analogues thereof
专利号:US-2015073145-A1 优先权日:2011-11-01 标 题:Modular synthesis of graphene nanoribbons and graphene substructures from oligo-alkynes
专利号:WO-2024038357-A1 优先权日:2022-08-16 标 题:Synthesis of substituted tetracyclic carboxylic acids and analogues thereof 发明人:CHEN SHUAI; COLE ANDREW G; GOTCHEV DIMITAR B; MASON JEREMY; PALLERLA MAHESH KUMAR; PAMULAPATI GANAPATI REDDY; SPINK JAN MICHELLE 权利人:ARBUTUS BIOPHARMA CORP 摘要:The present disclosure includes synthetic methods for preparing certain substituted tetracyclic carboxylic acids, which can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) infections in a patient.
专利号:CA-2744197-A1 优先权日:2008-12-01 标 题 :Synthesis and novel salt forms of (r)-3-((e)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
参考文献:10.1038/nchem.1504 摘要:Goetz AE, Garg NK. Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model. Nature Chemistry. 2012 Nov 25;5(1):54–60. doi: 10.1038/nchem.1504. 参考文献:10.1007/bf02996300 摘要:Saji H, Ogawa M, Ueda M, Iida Y, Magata Y, Tominaga A, Kawashima H, Kitamura Y, Nakagawa M, Kiyono Y, Mukai T. Evaluation of radioiodinated 5-iodo-3-(2(S)-azetidinylmethoxy)pyridine as a ligand for SPECT investigations of brain nicotinic acetylcholine receptors. Ann Nucl Med. 2002 May;16(3):189–200. doi: 10.1007/bf02996300.