📜2-甲氧基对苯二酚置于甲酸,Jones Reagent,Sodium Hydride,Potassium Carbonate体系中,用 水,丙酮,Paraffin,苯 作为反应溶剂,化学反应 31.5H,反应生成 早熟素ⅱ 参考文献:Uchiyama,M.; Overeem,J. C.,Recueil Des Travaux Chimiques Des Pays-Bas,1981,Vol. 100,# 11,P. 408-410 标题:Uchiyama,M.; Overeem,J. C.,Recueil Des Travaux Chimiques Des Pays-Bas,1981,Vol. 100,# 11,P. 408-410
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:WO-2021074309-A1 优先权日:2019-10-16 标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)
专利号:WO-2021074311-A1 优先权日:2019-10-16 标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)
专利号:US-12213481-B1 优先权日:2023-12-29 标 题 :4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.) 发明人:AHMED HANY MOHAMED ABD EL-LATEEF; ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A 权利人:UNIV KING FAISAL 摘要:Synthesis of a compound 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde and its use as an insecticidal agent.
专利号:US-12060336-B1 优先权日:2023-12-27 标题:(2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.) 发明人:ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED A; AHMED HANY MOHAMED ABD EL-LATEEF; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A 权利人:UNIV KING FAISAL 摘要:Synthesis of a compound (2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide and its use as an insecticidal agent.
专利号:US-11998014-B1 优先权日:2024-01-03 标题:O-{1-[(3,5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.) 发明人:AHMED HANY MOHAMED ABD EL-LATEEF; ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A 权利人:UNIV KING FAISAL 摘要:Synthesis of a compound O-{1-[(3.5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate and its use as an insecticidal agent.
1: Ramadan KMA, El-Beltagi HS, Iqbal Z, Bendary ESA. The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III. Molecules. 2022 Oct 24;27(21):7177. doi: 10.3390/molecules27217177. 2: Sukmawan YP, Anggadiredja K, Adnyana IK. Anti-neuropathic Pain Mechanistic Study on A. conyzoides Essential Oil, Precocene II, Caryophyllene, or Longifolene as Single Agents and in Combination with Pregabalin. CNS Neurol Disord Drug Targets. 2023;22(6):924-931. doi: 10.2174/1871527321666220418121329. 12(6):101818. doi: 10.1016/j.ttbdis.2021.101818. Epub 2021 Sep 4. 11(4):224. doi: 10.3390/insects11040224. 5: Huang J, Fang L, Wang S, Liu X, Chen Y, Chen Y, Tian H, Lin S, Tian S, Wei H, Gu X. Molecular cloning, expression profiling, and functional analysis of a broad-complex isoform 2/3 (Br-Z2/Z3) transcription factor in the diamondback moth, Plutella xylostella (L.). Arch Insect Biochem Physiol. 2019 Jun;101(2):e21549. doi: 10.1002/arch.21549. Epub 2019 Apr 3. 7(2):342-9. doi: 10.1016/j.ttbdis.2015.12.005. Epub 2015 Dec 9. 80(1):43-54. doi: 10.1080/09168451.2015.1086261. Epub 2015 Sep 17. 10(8):e0135031. doi: 10.1371/journal.pone.0135031.
合成参考文献
摘要:Xiao, X., Science of Synthesis: Knowledge Updates, (2023) 2, 159. 参考文献:10.1007/bf01975096 摘要:Culvenor CCJ, Clarke M, Edgar JA, Frahn JL, Jago MV, Peterson JE, Smith LW. Structure and toxicity of the alkaloids of Russian comfrey (Symphytum x uplandicum Nyman), a medicinal herb and item of human diet. Cellular and Molecular Life Sciences. 1980 Apr;36(4):377–9. doi: 10.1007/bf01975096. 参考文献:10.1007/bf01975098 摘要:Lightner DA, Wooldridge TA, Rodgers SL, Norris RD. Action spectra for bilirubin photodisappearance. Cellular and Molecular Life Sciences. 1980 Apr;36(4):380–2. doi: 10.1007/bf01975098. 参考文献:10.1002/arch.10027 摘要:Stebbings H. Perturbed turnover of microtubule-based nutritive tubes in ovarioles of virgin and precocene-treated Dysdercus fasciatus. Arch Insect Biochem Physiol. 2002 May;50(1):31–40. doi: 10.1002/arch.10027.