CAS: 644-06-4; Precocene Ii

该化合物是青少年激素对抗者的合成类比,主要用于昆虫研究,其主要优势在于它能够通过抑制青少年荷尔蒙生物合成来干扰昆虫的发育,导致目标物种的先天变形或不育.该复合物对于研究昆虫的激素调控和虫害管理研究具有特别价值.前二为某些昆虫的订单展示了特殊性,使它成为选择性研究的有用工具.在实验室条件下,其精细化的行动和稳定性机制有助于其在实验环境中的可靠性.该化合物通常用于受控研究昆虫内分泌学和发育生物学.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号2033-89-8 3,4-二甲氧基苯酚 | CAS号107-86-8 异戊烯醛 | CAS号75188-80-6 N-(7-amino-8-(4... | CAS号34191-88-3 1,2-dimethoxy-4... | CAS号74094-51-2 7-methoxy-2,2-d... | CAS号74-88-4 碘甲烷 | CAS号62470-72-8 6,7-dimethoxy-2... | CAS号491-37-2 2,3-二氢苯并吡喃-4-酮 | CAS号65383-61-1 6,7-二甲氧基-2,2-二甲... | CAS号69888-42-2 3,4-dihydro-6,7... | CAS号89004-22-8 6,7-dimethoxy-2... | CAS号62471-06-1 5,6-dimethoxy-2...

合成工艺路线路线简述

    📜2-甲氧基对苯二酚置于甲酸,Jones Reagent,Sodium Hydride,Potassium Carbonate体系中,用 水,丙酮,Paraffin,苯 作为反应溶剂,化学反应 31.5H,反应生成 早熟素ⅱ
    参考文献:Uchiyama,M.; Overeem,J. C.,Recueil Des Travaux Chimiques Des Pays-Bas,1981,Vol. 100,# 11,P. 408-410
    标题:Uchiyama,M.; Overeem,J. C.,Recueil Des Travaux Chimiques Des Pays-Bas,1981,Vol. 100,# 11,P. 408-410

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-12213481-B1
    优先权日:2023-12-29
    标 题 :4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)
    发明人:AHMED HANY MOHAMED ABD EL-LATEEF; ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A
    权利人:UNIV KING FAISAL
    摘要:Synthesis of a compound 4,4′-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde and its use as an insecticidal agent.

    专利号:US-12060336-B1
    优先权日:2023-12-27
    标题:(2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)
    发明人:ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED A; AHMED HANY MOHAMED ABD EL-LATEEF; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A
    权利人:UNIV KING FAISAL
    摘要:Synthesis of a compound (2E)-4-[(4-chlorophenyl)amino]-N-phenyl-2-(phenylimino)-1,3,5-dioxazepine-7-carboxamide and its use as an insecticidal agent.

    专利号:US-11998014-B1
    优先权日:2024-01-03
    标题:O-{1-[(3,5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate as an eco-friendly insecticidal agent against Spodoptera littoralis (boisd.)
    发明人:AHMED HANY MOHAMED ABD EL-LATEEF; ALI MAI MOSTAFA KHALAF; GOUDA MOHAMED; AHMED ANTAR AHMED ABDELHAMID; GAD MOHAMED A
    权利人:UNIV KING FAISAL
    摘要:Synthesis of a compound O-{1-[(3.5-dinitrobenzoyl)amino]propan-2-yl} (4-chlorophenyl)carbamothioate and its use as an insecticidal agent.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Ramadan KMA, El-Beltagi HS, Iqbal Z, Bendary ESA. The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III. Molecules. 2022 Oct 24;27(21):7177. doi: 10.3390/molecules27217177.
    2: Sukmawan YP, Anggadiredja K, Adnyana IK. Anti-neuropathic Pain Mechanistic Study on A. conyzoides Essential Oil, Precocene II, Caryophyllene, or Longifolene as Single Agents and in Combination with Pregabalin. CNS Neurol Disord Drug Targets. 2023;22(6):924-931. doi: 10.2174/1871527321666220418121329. 12(6):101818. doi: 10.1016/j.ttbdis.2021.101818. Epub 2021 Sep 4. 11(4):224. doi: 10.3390/insects11040224.
    5: Huang J, Fang L, Wang S, Liu X, Chen Y, Chen Y, Tian H, Lin S, Tian S, Wei H, Gu X. Molecular cloning, expression profiling, and functional analysis of a broad-complex isoform 2/3 (Br-Z2/Z3) transcription factor in the diamondback moth, Plutella xylostella (L.). Arch Insect Biochem Physiol. 2019 Jun;101(2):e21549. doi: 10.1002/arch.21549. Epub 2019 Apr 3. 7(2):342-9. doi: 10.1016/j.ttbdis.2015.12.005. Epub 2015 Dec 9. 80(1):43-54. doi: 10.1080/09168451.2015.1086261. Epub 2015 Sep 17. 10(8):e0135031. doi: 10.1371/journal.pone.0135031.

    合成参考文献


    摘要:Xiao, X., Science of Synthesis: Knowledge Updates, (2023) 2, 159.
    参考文献:10.1007/bf01975096
    摘要:Culvenor CCJ, Clarke M, Edgar JA, Frahn JL, Jago MV, Peterson JE, Smith LW. Structure and toxicity of the alkaloids of Russian comfrey (Symphytum x uplandicum Nyman), a medicinal herb and item of human diet. Cellular and Molecular Life Sciences. 1980 Apr;36(4):377–9. doi: 10.1007/bf01975096.
    参考文献:10.1007/bf01975098
    摘要:Lightner DA, Wooldridge TA, Rodgers SL, Norris RD. Action spectra for bilirubin photodisappearance. Cellular and Molecular Life Sciences. 1980 Apr;36(4):380–2. doi: 10.1007/bf01975098.
    参考文献:10.1002/arch.10027
    摘要:Stebbings H. Perturbed turnover of microtubule-based nutritive tubes in ovarioles of virgin and precocene-treated Dysdercus fasciatus. Arch Insect Biochem Physiol. 2002 May;50(1):31–40. doi: 10.1002/arch.10027.
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