CAS: 638-32-4; 4-Amino-4-Oxobutanoic Acid

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CAS号123-56-8 丁二酰亚胺 | CAS号108-30-5 丁二酸酐 | CAS号67-56-1 甲醇 | CAS号38457-08-8 Butanedioic aci... | CAS号2226-88-2 丁二酸铵 | CAS号617-65-2 DL-谷氨酸 | CAS号631-61-8 乙酸铵 | CAS号64-19-7 冰醋酸 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号3878-55-5 丁二酸单甲酯 | CAS号123-56-8 丁二酰亚胺 | CAS号1121-07-9 N-甲基琥珀酰亚胺 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号56269-39-7 Butanoic acid,4... | CAS号7732-18-5 水 | CAS号53171-39-4 琥珀酰胺酸甲酯 | CAS号57-13-6 尿素 | CAS号71067-27-1 N,N'-dibenzylbu...

📜丁二酰亚胺置于trifluoromethanesulphonamide Sodium Salt体系中,用 水 作为反应溶剂,化学反应 6.0H,以44%的收率获得产物丁酰胺酸
参考文献:γ-二羧酸酰胺和酰亚胺与三氟甲磺酰胺和甲醛的反应
标题:γ-二羧酸酰胺和酰亚胺与三氟甲磺酰胺和甲醛的反应
摘要:三氟甲磺酰胺与低聚甲醛和琥珀酰胺的三组分缩合反应取决于反应条件,与双三氟甲烷磺酰胺基甲烷一起导致取代产物双[(三氟甲基磺酰基)氨基甲基]琥珀酰胺的形成,或环化产物n-[三氟甲基磺酰基]的形成氨基甲基]琥珀酰亚胺.通过三氟甲磺酰胺钠盐cf 3 So 2 Nhna与n-氯甲基琥珀酰亚胺的反应来获得后者的尝试出乎意料地导致了n,N-双(琥珀酰亚胺基甲基)-三氟甲磺酰胺.类似地,Cf 3 So 2 Nhna与n的反应-氯甲基-邻苯二甲酰亚胺得到n,N-双(邻苯二甲酰亚胺基甲基)三氟甲磺酰胺.cf 3 So 2 Nhna与琥珀酰亚胺和邻苯二甲酰亚胺在水和醇溶液中的反应导致开环并进一步转化形成的琥珀酸和邻苯二甲酸的单取代n-(三氟甲基磺酰基)酰胺.
DOI:10.1134/s1070428009110116

专利信息

专利号:WO-2017175233-A1
优先权日:2016-04-04
标 题:Process for large scale liquid phase synthesis of carbetocin and its novel intermediates
发明人：Mohammed Khalid Anwer; Mohammed Mohosin Layek
权利人:DAVULURI RAMAMOHAN RAO
摘要:A process for large scale liquid phase synthesis of Carbetocin is disclosed. Novel intermediates of formula (A), formula (B), and processes for their preparation are also disclosed.

专利号:US-7691635-B2
优先权日:2004-03-26
标题 :Labeling reagents, methods for the synthesis of such reagents and methods for the detection of biological molecules
发明人：LAAYOUN ALI; BERNAL-MENDEZ ELOY
权利人:BIOMERIEUX SA
摘要:The present invention relates to a temperature-stable labeling reagent of formula (0): n nin which:n R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers interlinked by at least one multimeric structure, L is a linker arm comprising a linear chain of at least two covalent bonds and n is an integer equal to 0 or 1, R 3 and R 4 represent, independently of one another: H, NO 2 , Cl, Br, F, I, R 2 -(L) n -Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR, —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 3 —CH 2 —NH—R 2 , —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 4 —CH 2 —NH—R 2 with R=alkyl or aryl, A is a linker arm comprising at least one covalent double bond enabling the conjugation of the diazo function with the aromatic ring and u is an integer between 0 and 2, preferably 0 or 1, —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—, —Z— represents —NH—, —NHCO—, —CONH— or —O—, m is an integer between 1 and 10, preferably between 1 and 3, and p is an integer between 1 and 10, preferably between 1 and 3. n The present invention also describes a method for the synthesis of said labels and also applications for the labeling of biological molecules, in particular of nucleic acids, with a labeling reagent bearing the diazomethyl function. n The invention is particularly suitable for use in the field of diagnostics.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:EP-2690438-A1
优先权日:2012-07-24
标题:Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from toxoplasma gondii and their application as diagnostic markers and vaccines
发明人：AZZOUZ NAHID; GOETZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to the synthesis of compounds derived from glycosylphosphatidylinositol (GPI) glycolipids from Toxoplasma gondii and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis and for use as a vaccine against diseases caused by infection with T. gondii.

专利号:US-9802974-B2
优先权日:2012-07-24
标 题 :Synthesis of diverse glycosylphosphatidylinositol glycans from Toxoplasma gondii and their application as vaccines and diagnostics
发明人：AZZOUZ NAHID; GÖTZE SEBASTIAN; SEEBERGER PETER H; SILVA DANIEL VARON; TSAI YU-HSUAN
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention relates to the synthesis of GPI-related surface antigens of the parasite Toxoplasma gondii ( T. gondii ) and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis, as well as vaccine against toxoplasmosis, a diseases caused by infection with T. gondii.

专利号:US-12060315-B2
优先权日:2019-02-14
标 题:Production processes of S- and O-diacylated gamma-glutamyl-cysteamine prodrugs
发明人：ANDERSON ROSALEEN JOY; FROST LISA; BARNWELL NEIL; LEVICK MATTHEW; HALES IVAN; DUNN MICHAEL
权利人:UNIV OF SUNDERLAND
摘要:Methods are provided for the synthesis of a compound of formula (X). R 2 is selected from —H, —C 1 -C 4 -alkyl, —C 2 -C 4 -alkenyl and C 1 -C 4 -aryl; R 3 is selected from —C(O)H and —C(O)C 1 -C 4 -alkyl; and A is a pharmaceutically acceptable anion (e.g. a halide). Also provided are intermediate compounds formed during the synthesis.