专利号:WO-2011097717-A1 优先权日:2010-02-15 标 题 :Synthesis of bicyclic compounds and method for their use as therapeutic agents 发明人:WULFF JEREMY EARLE; BRANT MICHAEL GLENN; BROMBA CALEB MATTHEW; BOULANGER MARTIN JOHN 权利人:UNIV VICTORIA INNOVAT DEV; WULFF JEREMY EARLE; BRANT MICHAEL GLENN; BROMBA CALEB MATTHEW; BOULANGER MARTIN JOHN 摘要:Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
专利号:US-8883846-B2 优先权日:2010-02-15 标题:Synthesis of bicyclic compounds and method for their use as therapeutic agents 发明人:WULFF JEREMY E; BRANT MICHAEL G; MASON JEREMY W; BROMBA CALEB M; BOULANGER MARTIN J 权利人:WULFF JEREMY E; BRANT MICHAEL G; MASON JEREMY W; BROMBA CALEB M; BOULANGER MARTIN J; UVIC INDUSTRY PARTNERSHIPS INC 摘要:Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
专利号:WO-8504598-A1 优先权日:1984-04-05 标题:Catalyst, process for its preparation and use thereof in conversion of synthesis gas to hydrocarbons 发明人:ATKINS MARTIN PHILIP; NAY BARRY 权利人:BRITISH PETROLEUM CO PLC 摘要:A composition suitable for use after activation as a catalyst or a support therefor in the conversion of synthesis gas to hydrocarbons comprising a porous, essentially amorphous framework matrix comprising at least one element present in the form of a hydrolysed compound thereof, for example silicon and aluminium, and distributed uniformly throughout the framework matrix at least one metal selected from Groups VIa and VIII of the Periodic Table, for example iron, cobalt, nickel and/or ruthenium. Also a process for the production of the composition involving a hydrolysis step and a process for converting synthesis gas to hydrocarbons using the activated composition as catalyst.
专利号:US-2013210904-A1 优先权日:2010-02-15 标 题 :Synthesis of bicyclic compounds and method for their use as therapeutic agents
专利号:US-4717770-A 优先权日:1986-02-27 标 题:Process for producing epsilon-caprolactam 发明人:SATO HIROSHI; HIROSE KENICHI; KITAMURA MASARU; TOJIMA HIDETO; ISHII NORIO 权利人:SUMITOMO CHEMICAL CO 摘要:ε-caprolactam is prepared by gas phase catalytic synthesis where cyclohexanone oxime is brought into contact with a crystalline zeolite, for example, aluminosilicate zeolite or metallosilicate zeolite having a constraint index of 1-12 which has been surface treated with an organometallic compound represented by the general formula: R 4-n MX n wherein R which may be identical or different represent an alkyl group of 1-6 carbon atoms or phenyl group, M represnets Si or Ge, X represents Cl or an alkoxy group of 1-6 carbon atoms and n represents 1 or 2.
专利号:EP-0162554-A1 优先权日:1984-04-05 标题:Catalyst, process for its preparation and use thereof in conversion of synthesis gas to hydrocarbons
参考标题:Pyrrolidine Catalyzed Novel Domino Reaction For The Synthesis Of Polysubstituted 4-Oxocyclohexanecarbaldehyde Derivatives 作者:Feng-Zu Bao,Xiao-Bing Wang,Ling-Yi Kong |发布日期:2013.3 摘要:Novel Domino Reaction Catalyzed By An Organic Molecule Based On α,β-Unsaturated Aromatic Aldehydes And Methylethylketones Has Been Developed. The Progress Allows One-Pot And Efficient Synthesis Of Polysubstituted 4-Oxocyclohexanecarbaldehyde Derivatives Via Pyrrolidine Mediated Under Mild Conditions. The Reaction Consists Of Three Consecutive Reactions: An Aldol Condensation Reaction And A Tandem
合成参考文献
参考文献:10.1134/s1070427224010063 摘要:Jasim ZI, Rashid KH, Khadom AA. Corrosion and Corrosion Control of the Steel in Acidizing Oil Wells Processes: An Overview of Organic Inhibitors. Russ J Appl Chem. 2024 Jan;97(1):56–74. doi: 10.1134/s1070427224010063.