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CAS号6515-09-9 2,3,6-三氯吡啶 | CAS号7664-93-9 硫酸 | CAS号136888-26-1 5,6-二氯-1H-吡咯并[3...

2,3,6-三氯吡啶置于硫酸,硝酸体系中,化学反应 8.0H,以64.7%的收率获得产物2,3,6-三氯-5-硝基吡啶
参考文献:Indole And Azaindole Derivative Having Ampk-Activating Activity
标题:Indole And Azaindole Derivative Having Ampk-Activating Activity
摘要:本申请公开了一种作为ampk激活剂有用的化合物.一种由以下结构表示的化合物或其药学上可接受的盐,其中y被取代或未取代的烷基,取代或未取代的烯基,取代或未取代的炔基,取代或未取代的芳基,取代或未取代的杂环芳基,取代或未取代的环烷基,取代或未取代的环烯基,或取代或未取代的杂环烷基;t为-cr7═或-n═;u为-cr8═或-n═;r2为氢,卤素,氰基,硝基,羧基,取代或未取代的烷基,取代或未取代的烯基,取代或未取代的酰基,取代或未取代的氨基甲酰基,取代或未取代的烷基硫基,取代或未取代的烷基亚砜基,取代或未取代的烷基砜基,或取代或未取代的烷氧羰基;r3为卤素,取代或未取代的烷基,取代或未取代的烯基,取代或未取代的炔基,取代或未取代的芳基,取代或未取代的杂环芳基,取代或未取代的环烷基,取代或未取代的环烯基,取代或未取代的杂环烷基,或类似物;且r4,R7和r8分别独立地为氢,卤素,羟基,氰基,硝基,羧基,取代或未取代的烷基,取代或未取代的烯基,取代或未取代的炔基,取代或未取代的芳基,取代或未取代的杂环芳基,取代或未取代的环烷基,取代或未取代的环烯基,取代或未取代的杂环烷基,或类似物.

专利信息

专利号:US-9815842-B2
优先权日:2014-05-28
标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors
发明人：SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS
权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG
摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.