CAS: 51114-94-4; (2-Carboxyethyl)Triphenylphosphonium Bromide

上下游产品

3-Bromopropionic acid triphenylphosphine 2,3-dibromopropionic acid trans 4-(3-hydroxy-4-methoxyphenyl)but-3-enoic acid (Z)-6-benzyloxy-5,5-dimethyl-3-hexenoic acid 3-Carboxypropylidenetriphenylphosphorane trans-styrylacetic acid

3-溴丙酸,三苯基膦 以 甲苯 作为反应溶剂,化学反应 4.0H,以93%的收率获得产物2-羧乙基三苯基溴化磷
参考文献:与靶向线粒体atp敏感钾通道的二氮嗪有关的1,2,4-苯并噻二嗪1,1-二氧化物的三苯基phosph盐
标题:与靶向线粒体atp敏感钾通道的二氮嗪有关的1,2,4-苯并噻二嗪1,1-二氧化物的三苯基phosph盐
摘要:本工作旨在确定能够靶向线粒体atp敏感性钾通道(mitok Atp通道)的新型离子通道调节剂.一种创新方法应包括将阳离子和疏水性三苯基phosph片段固定在已知的k Atp通道开放剂的结构上.预期此类phospho盐穿过生物膜并积聚到线粒体中. 先前的工作表明,在大多数情况下,在4 H-1,2,4-苯并噻二嗪1,1-二氧化物k Atp通道开放剂的3位上存在(R)-1-羟基-2-丙基氨基链,对胰腺型(sur1 / Kir6.2)k Atp通道的选择性.为了靶向心脏mitok Atp通道,我们决定通过sur1选择性(R)-7-氯-3-(1-羟基-2-丙基)氨基-4 H-1上的酯键引入三苯基phosph基团,2,4-苯并噻二嗪1,1-二氧化物.发现新化合物保留了对胰岛素分泌的抑制活性(sur1型k Atp通道开放剂),但没有观测到明显的证据表明心肌细胞对线粒体有影响(氧气消耗量,呼吸参数和h
DOI:10.1016/j.Bmcl.2013.08.091

专利信息

专利号:WO-2023137518-A1
优先权日:2022-01-21
标题 :Platinum complexes
发明人：ALDRICH-WRIGHT JANICE; GORDON CHRISTOPHER; DEO KRISHANT M; KHOURY ALEEN; MCGHIE BRONDWYN; APUTEN ANGELICO; PLATTEN-MENTI MARIA; RASHID FATIN; JURISINEC ASHLEY; SOLIMAN SARAH
权利人:WESTERN SYDNEY UNIV
摘要:The present disclosure relates to platinum complexes, and in particular platinum(II) and platinum(IV) complexes. The present disclosure also relates to synthesis of the platinum complexes, and to intermediates for the synthesis of the platinum complexes. The present disclosure also relates to methods and use of the platinum complexes for treating cancer.

专利号:US-12144874-B2
优先权日:2015-09-09
标题 :Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
发明人：KULARATNE SUMITH A; GAGARE PRAVIN
权利人:ON TARGET LABORATORIES LLC; ON TARGET LABORATORIES INC
摘要:The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

专利号:US-10676487-B2
优先权日:2015-09-09
标 题 :Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer
发明人：KULARATNE SUMITH A; GAGARE PRAVIN; MYERS CARRIE H
权利人:ON TARGET LABORATORIES LLC
摘要:The present invention describes new compounds that are useful for image-guided surgery and photodynamic therapy. In particular the compounds may be targeted to the nucleus or the mitochondria after compounds were delivered to diseased tissues such as cancer using a ligand that target receptor that express on the diseased tissue and followed by receptor mediated endocytosis and provide effective activity against cancer cells as well as other disorders. Methods and compositions for use of the same are described.

专利号:WO-2017044445-A1
优先权日:2015-09-09
标题 :Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer

专利号:US-6433167-B1
优先权日:1997-06-25
标题 :Triazolo-1,4-diazepine compounds and medicinal composition containing the same
发明人：FUJITA MASAKAZU; SEKI TAKETSUGU; INADA HARUAKI; SANO TETSURO
权利人:NIKKEN CHEMICALS CO LTD
摘要:A triazolo-1,4-diazepine compound having the formula (I): n wherein A represents CO, CO—B, or B, B represents a C 1 to C 6 alkylene group or a C 2 to C 6 alkylene group having an oxygen atom interposed in the middle thereof, X represents N—O or CH, n represents an integer of 2 to 6, R represents a hydroxyl group, a C 1 to C 6 lower alkyloxy group or a C 1 to C 6 lower alkylamino group, provided that these groups may be substituted with an N,N-dimethylamino group, an N,N-diethylamino group, a phenyl group, or a heterocyclic group, and R 1 represents a hydrogen atom or a C 1 to C 3 lower alkyl group having both a PAF antagonistic action and a thromboxane synthesis inhibiting action, and a pharmaceutical composition containing the same as an active ingredient.

专利号:EP-3347010-A1
优先权日:2015-09-09
标题:Synthesis and composition of photodynamic therapeutic agents for the targeted treatment of cancer