CAS: 50681-25-9; 4-Pyridazinecarboxylic Acid

相似化合物

68776-62-5 50901-43-4 59648-14-5

上下游产品

pyridazine-4,5-dicarboxylic acid pyridazine-3,4-dicarboxylic acid 6-ethoxy-3,4-diethoxycarbonyl-1-methoxycarbonyl-1,4,5,6-tetrahydropyridazine pyridazine-3,4-dicarboxylic acid diethyl ester methyl pyridazine-4-carboxylate 5-(4-chloro-benzoyl)-pyridazine-4-carboxylic acid 5-(2-Chloro-benzoyl)-pyridazine-4-carboxylic acid 5-benzoyl-pyridazine-4-carboxylic acid

4-甲基哒嗪置于acetyl Peroxyborate体系中,用 水 作为反应溶剂,化学反应 5.0H,以100 Mol %的收率获得产物4-哒嗪羧酸
参考文献:使用单中心非均相催化剂,一步一步即可生产烟酸(维生素b3)和其他含氮药物.
标题:使用单中心非均相催化剂,一步一步即可生产烟酸(维生素b3)和其他含氮药物.
摘要:可以在食品中生产烟酸(3-吡啶甲酸),广泛用作食品中的维生素b3和降胆固醇剂,以及甲基吡啶,4-甲基喹啉和其他嘧啶和哒嗪的其他氧化产物.通过在不存在有机溶剂的情况下,将单中心,开放结构的多相催化剂与活性氧的固体来源(即乙酰过氧硼酸盐(apb))结合使用,从而实现对环境友好的一步式生产.这种单中心非均相催化剂所具有的高活性,选择性和相对温和的条件,以及易于运输,储存和固体氧化剂的稳定性,为apb与其他开放式结构的未来使用预示了非常好的前景.,适用于精细化工,制药和农业化学应用的单中心催化剂.
DOI:10.1002/chem.200701679

专利信息

专利号:US-6025492-A
优先权日:1996-08-30
标 题 :Synthesis of a hydrazone β-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO CO
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.

专利号:EP-0923540-B1
优先权日:1996-08-30
标题 :Synthesis of a hydrazone beta-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazo ester with a hydrazone aldehyde in the presence of a Lewis acid. In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. The present invention also relates to a continuous process for the production of a hydrazone aldehyde comprising contacting a hydrazine and glyoxal, wherein the hydrazine and the glyoxal are added simultaneously to a reactor at a controlled rate.

专利号:US-4835280-A
优先权日:1985-01-18
标 题 :Indoline compounds for synthesis of pharmaceutically active pyrrolobenzimidazoles
发明人：MARTENS ALFRED; HOELCK JENS-PETER; BERGER HERBERT; MUELLER-BECKMAN BERND; STREIN KLAUS; ROESCH EGON
权利人:BOEHRINGER MANNHEIM GMBH
摘要:The present invention provides Indolines of the formula: (II) (III) ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula: (I) These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

专利号:US-7838680-B2
优先权日:2006-04-03
标 题:Process for preparing heterocyclic derivatives
发明人：BACCHI SERGIO
权利人:GLAXO GROUP LTD
摘要:The present invention relates to a novel process, useful for preparing key intermediates of formula (I) in the synthesis of various compounds, among them compounds which are potent and specific antagonists of D3 receptors, n nin whichn X may be Nitrogen or Sulfur; Het means aryl or heteroaryl; each of which may be substituted by 1 to 4 groups J selected from:n halogen, C1-C6 alkyl C1-C6 alkoxy, halo C1-C6 alkyl C2-C6 alkenyl, C2-C6 alkynyl, halo C1-C6 alkoxy, —C(O)R 1 , nitro, hydroxy, —NR 2 R 3 , cyano or a group Z; n R 1 is a C1-C4 alkyl —OR 3 or —NR 3 R 4 ; R 2 is hydrogen or C1-C6 alkyl; R 3 is hydrogen or C1-C6 alkyl; R is H, C1-C6 alkyl aryl, benzyl; each of which may be substituted by 1 to 4 groups J; according to the following Scheme 1: n nin whichn step a means a reaction in basic conditions of compounds (IIA) with 3-thiosemicarbazide derivatives, followed by a treatment with an inorganic base and n-propane phosphonic cyclic anhydride and final pH adjustment with inorganic acids to give compounds of formula (II).

专利号:WO-9808807-A1
优先权日:1996-08-30
标题:SYNTHESIS OF A HYDRAZONE β-KETO ESTER BY THE REACTION WITH A DIAZO ESTER

专利号:EP-0923540-A1
优先权日:1996-08-30
标 题:Synthesis of a hydrazone beta-keto ester by the reaction with a diazo ester