CAS: 462-72-6; 1-Bromo-4-Fluorobutane

该化合物是一种有机化合物,其特征是丁烷脊柱上既有溴和氟替代成分,其分子式为C4H8BRF,表明含有4个碳原子,8个氢原子,1个溴原子和1个氟原子.该化合物在室温下一般是无色的,不光彩的黄色液体,与其他卤化碳氢化合物相比,呈现温和的沸点和密度.溴和氟原子的存在有助于其再活动,使其在各种化学合成中有用,包括核生殖替代反应.此外,1-溴-4-氟丁烷由于卤素和碳之间的电效应差异而具有极性,这可能会影响其在不同溶剂中的溶解性.重要的是要谨慎地处理这一化合物,因为卤化有机化合物可能对环境和健康造成危害.

结构式图片

相似化合物

407-97-6 352-91-0 110-52-1

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号110-52-1 1,4-二溴丁烷 | CAS号372-93-0 4-氟-1-丁醇 | CAS号353-17-3 Thi°Cyanic acid... | CAS号353-13-9 5-Fluorovaleron... | CAS号372-82-7 1-fluoro-4-nitr... | CAS号648956-83-6 2-(4-fluorobuty...

合成工艺路线路线简述

  • 合成目标产物 1-Bromo-4-Fluorobutane 主要起始原料 1,4-Dibromobutane
  • (文献来源)合成步骤主要原料 1,4-Dibromobutane
4-氟-1-丁醇置于三溴化磷体系中,化学反应生成 1-溴-4-氟丁烷
参考文献:Physical And Mechanical Properties Of Pea-Protein-Based Edible Films
标题:Physical And Mechanical Properties Of Pea-Protein-Based Edible Films
摘要:Abstract: Edible Films Produced From Denatured Pea Protein Concentrate (Ppc) Solution Possessed The Strength And Elasticity To Resist Handling. Increasing The Concentration Of The Plasticizer (Glycerol) In The Film Decreased Tensile Strength And Elastic Modulus,And Increased Elongation And Water Vapor Permeability (Wvp). Very Strong And Stretch‐able Films Were Obtained From 70/30 And 60/40 Of Ppc/glycerol Composition,Respectively. The Low Wvp Value Was Maintained Over A Range Of Glycerol Concentration From 20% To 40%,In The Dry Film. Film Solubility Was Not Affected Significantly By The Amount Of The Plasticizer. The Physical And Mechanical Properties Of The Ppc Films Were Comparable With Those Of Soy Protein And Whey Protein Films.
DOI:10.1111/j.1365-2621.2001.Tb11339.X

海关参考信息

专利信息


专利号:US-8975427-B2
优先权日:2010-04-28
标题 :Synthesis of alkyl cyclopentadiene compounds
发明人:HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C
权利人:HARLAN C JEFF; CAO XIANYI; RIX FRANCIS C; UNIVATION TECH LLC
摘要:A method of synthesizing an alkyl cyclopentadiene compound is disclosed. The method includes contacting at least one cyclopentadienyl anion source and at least one alkyl group source to form at least one alkyl cyclopentadiene compound. The method further includes extracting the alkyl cyclopentadiene compound with a hydrocarbon solvent. The alkyl cyclopentadiene compound may be converted to a metallocene catalyst compound.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人:THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:EP-0951466-B1
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人:WU JING; TUNG JAY S; THORSETT EUGENE D; PLEISS MICHAEL A; NISSEN JEFFREY S; NEITZ JEFFREY; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; DROSTE JAMES J; HENRY STEVEN S; MCDANIEL STACEY L; SCOTT WILLIAM L; STUCKY RUSSELL D
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds for Formula (I) wherein the substituents are as defined in the claims which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2013085289-A1
优先权日:2010-04-28
标题:Synthesis of Alkyl Cyclopentadiene Compounds
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主要参考文献

参考标题:Diversity‐oriented Synthesis Of Aliphatic Fluorides Via Reductive C(Sp3)−c(Sp3) Cross‐coupling Fluoroalkylation
作者:Jie Sheng,Hui‐qi Ni,Shan‐xiu Ni,Yan He,Ru Cui,Guang‐xu Liao,Kang‐jie Bian,Bing‐bing Wu,Xi‐sheng Wang |发布日期:2021.6.25
摘要:Catalyst And Alkyl Bromide Whereas The Generation Of Monofluoroalkyl Radical Is Not Involved In The Rate-Determining Step. This Strategy Provides A General And Efficient Method For The Synthesis Of Aliphatic Fluorides.

合成参考文献


摘要:Journal of Organic Chemistry., 21(748), 1956
摘要:Compilation of LD50 Values of New Drugs.
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