CAS: 42772-85-0; 2-Hydroxyethyl 4-Methylbenzenesulfonate

该化合物是一种全氟辛烷磺酸酯衍生物,通常用作有机合成的中间体,其主要结构特征包括一个聚苯乙烯(p-toluensulfonyl)组和一个氢氧-羟-可功能乙烯桥,使其成为引入受保护酒精功能的多种试剂或作为核生殖替代反应中的留置组.化合物在标准处理条件下表现出稳定性,对浸泡物联结,聚合物化学和制药合成特别有用.其再活性可以微调,以适应选择性变异,提供合成灵活性.甲基苯乙烯基混合物的存在提高了其在有机溶剂中的溶性,促进了其在同质反应系统中的使用.

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物理性质

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CAS号107-21-1 乙二醇 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号104-15-4 对甲苯磺酸 | CAS号6123-63-3 4-乙酰-5-甲基-1-苯基吡唑 | CAS号542-59-6 乙酸-2-羟基乙酯 | CAS号6192-52-5 对甲苯磺酸一水合物 | CAS号75-21-8 环氧乙烷 | CAS号7182-86-7 四丁基对甲苯磺酸铵 | CAS号96-49-1 碳酸乙烯酯 | CAS号104575-26-0 2-(2,4-dimethyl... | CAS号713-46-2 2-(4-叔丁基苯氧基)乙醇 | CAS号41532-81-4 2-甲氧基乙氧基苯

合成工艺路线路线简述

    📜对甲苯磺酰氯置于potassium Iodide体系中,用 二氯甲烷,乙二醇 作为反应溶剂,化学反应生成 对甲苯磺酸羟乙酯
    参考文献:Use Of Novel Compound Having Affinity For Amyloid,And Process For Production Of The Same
    标题:Use Of Novel Compound Having Affinity For Amyloid,And Process For Production Of The Same
    摘要:该发明提供了一种用于检测生物组织中淀粉样蛋白的试剂,可以利用一种与淀粉样蛋白亲和力强且在毒性方面受到抑制(如致突变性)的化合物,在体外和体内高灵敏度地检测淀粉样蛋白.用于检测生物组织中沉积的淀粉样蛋白的试剂包括下式(1)所表示的化合物或其盐:其中a1,A2,A3和a4独立地代表碳或氮;r1是卤素取代基;r2是卤素取代基;m是整数或0到2,但至少r1和r2中的一个是放射性卤素取代基,A1,A2,A3和a4中至少一个代表碳,且r1与a1,A2,A3和a4所代表的碳结合.

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    专利信息


    专利号:US-2014309424-A1
    优先权日:2011-06-30
    标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine
    发明人：BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN
    权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA
    摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.

    专利号:WO-2025083208-A1
    优先权日:2023-10-19
    标题 :Synthesis of morpholine derivatives and compounds therefore
    发明人：BUESCHLEB MARTIN; BEAUFILS FLORENT; PROUDFOOT JOHN
    权利人:BOEHRINGER INGELHEIM INT
    摘要:The present invention relates to a synthesis method for morpholine derivatives, including a ring-formation out of a 1,2-amino alcohol and a compound of formula (I) whereby LG is a nucleophilic leaving group and R1 to R7 are as herein defined.

    专利号:US-2018016227-A1
    优先权日:2015-02-03
    标题:Process for the synthesis of difluoromethyl ether-based compounds
    发明人：SLASSI ABDELMALIK; DOVE PETER
    权利人:TRILLIUM THERAPEUTICS INC
    摘要:The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in particular as precursors for medicines for the treatment of diseases, disorders or conditions. In particular, the present application includes the process of preparing compounds of Formula (I), and compositions and uses thereof:

    专利号:WO-2013001088-A1
    优先权日:2011-06-30
    标 题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine

    专利号:EP-2751087-A1
    优先权日:2011-06-30
    标题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl)tyrosine

    专利号:WO-2012126088-A1
    优先权日:2011-03-23
    标 题:Method for the synthesis of dha

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    合成参考文献


    摘要:Compound: Poly(oxy-1,2-ethanediyl), α-[(4-methylphenyl)sulfonyl]-ω-hydroxy-
    摘要:Shcherbakova, I., Science of Synthesis, (2007) 31, 802.
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