CAS: 34686-71-0; 6-[(E)-Pent-2-Enyl]Oxan-2-One
该化合物是一个环状酯化合物,在由六人组成的内酯环上有一个pent-2-en-1-yl替代体,这种结构具有适合有机合成应用的回活动性,特别是在口味和香味中间体的开发方面.不饱和的侧链为进一步功能化提供了多种功能,包括氢化或交叉相交反应.它的内酯核心有助于稳定性,同时在受控条件下能够打开环状聚合或衍生.该化合物定义的分子结构使它成为精细化学品和特殊材料的宝贵建筑块.建议由于对氧化或聚合的潜在敏感性,在不饱和条件下进行适当的处理.
- 英文名称6-[(E)-Pent-2-Enyl]Oxan-2-One
- 中文名称四氢-6-(2-戊烯基)-2H-2-吡喃酮
- IUPAC名称6-pent-2-enyloxan-2-one
- 其它别名2H-Pyran-2-one,tetrahydro-6-(2-pentenyl)- (9CI); 7-Decenoic acid, 5-hydroxy-, d-lactone (7CI); 5-Hydroxy-7-decenoic acid lactone; d-2-Pentenylvalerolactone
- CAS编号34686-71-0
- MFCD编号:MFCD00036608
- EINECS号:252-148-2
- 分子式:C10H16O2分子量:168.23
- 产品CID: 1351080
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
严重眼刺激 类别2 - 警示词Warning(警告)
- 危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激. - 防范说明P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
- 安全声明(RIFM includes CAS Number 34686-71-0. Tetrahydro-6-(2-pentenyl)-2H-pyran-2-one in this published assessment because the materials are isomers.) The existing information was reviewed by the independent Expert Panel for Fragrance Safety and supports the use of 5-Hydroxy-7-decenoic acid δ-lactone as described in this safety assessment. Data from read-across material tetrahydro-6-(3-pentenyl)-2H-pyran-2-one (CAS # 32764-98-0) show that 5-hydroxy-7-decenoic acid δ-lactone is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 5-hydroxy-7-decenoic acid δ-lactone is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data show that there are no safety concerns for 5-hydroxy-7-decenoic acid δ-lactone for skin sensitization under the current declared levels of use. 5-hydroxy-7-decenoic acid δ-lactone is not expected to be phototoxic/photoallergenic based on an evaluation of the ultraviolet/visible (UV/Vis) spectra.
欧盟法规
ECHA物质C&L通报REACH预注册合成工艺路线路线简述
海关参考信息
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2901220000-丙烯
2905122000-异丙醇
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专利信息
专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人：SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.
专利号:CN-106946823-B
优先权日:2016-12-30
标 题 :A kind of method for asymmetric synthesis of (R)-natural jasmonolide
专利号:US-8546519-B2
优先权日:2007-10-09
标题 :Polyketal compounds, synthesis, and applications
发明人：SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING
权利人:SELIFONOV SERGEY; ROTHSTEIN SCOTT D; WICKS DOUGLAS A; MULLEN BRIAN D; MULLEN TARA J; PRATT JASON D; WILLIAMS CHARLES T; WU CHUNYONG; ZHOU NING; SEGETIS INC
摘要:The invention relates to polyketal compounds. The compounds are synthesized by the selective ketalization of oxocarboxylic acids, e.g. keto acids and semialdehydes, and esters thereof with tetrols and higher polyols that products two or more cyclic ketal ester moieties per molecule, wherein the cyclic ketal moieties are situated in a bis-, tris-, or polyketal conformation. The invention further relates to applications of these compounds and subsequent reactions thereof.
专利号:CN-104788407-A
优先权日:2015-04-24
标题 :The production method of transesterification synthesis methyldecalactone
专利号:CN-106946823-A
优先权日:2016-12-30
标 题 :A kind of method of asymmetric synthesis (R)-natural jasmonolactone
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/j.fct.2022.112853
摘要:Api AM, Belsito D, Botelho D, Bruze M, Burton GA, Buschmann J, Cancellieri MA, Dagli ML, Date M, Dekant W, Deodhar C, Fryer AD, Jones L, Joshi K, Kumar M, Lapczynski A, Lavelle M, Lee I, Liebler DC, Moustakas H, Na M, Penning TM, Ritacco G, Romine J, Sadekar N, Schultz TW, Selechnik D, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y, Tokura Y. RIFM fragrance ingredient safety assessment, 5-hydroxy-7-decenoic acid δ-lactone, CAS Registry Number 25524-95-2. Food Chem Toxicol. 2022 Mar;161 Suppl 1():112853. doi: 10.1016/j.fct.2022.112853.
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