CAS: 345-35-7; 1-(Chloromethyl)-2-Fluorobenzene

上下游产品

CAS号446-51-5 2-氟苄醇 | CAS号65108-14-7 o-fluorobenzyl ion | CAS号95-52-3 邻氟甲苯 | CAS号445-29-4 邻氟苯甲酸 | CAS号7647-01-0 盐酸 | CAS号56-23-5 四氯化碳 | CAS号50-00-0 甲醛 | CAS号462-06-6 氟苯 | CAS号5435-44-9 N-(1-ethoxycarb... | CAS号326-62-5 邻氟氰苄 | CAS号451-82-1 邻氟苯乙酸 | CAS号517920-60-4 2-氟苄基硼酸频哪醇酯 | CAS号150322-73-9 1-环丙基-2-(2-氟苯基)乙酮 | CAS号95-52-3 邻氟甲苯 | CAS号446-51-5 2-氟苄醇 | CAS号1759-53-1 环丙甲酸 | CAS号399-30-4 N-甲基-2-氟苄胺 | CAS号192997-17-4 1-(2-Fluoro-ben... | CAS号194288-97-6 4-[(2-氟苯基)甲基]哌啶

2-氟苄醇置于n,N-二甲基甲酰胺,邻氟苯甲酰氯体系中,用 二氯甲烷 作为反应溶剂,化学反应 12.0H,以80%的收率获得产物邻氟氯苄
参考文献:甲酰胺作为sn反应中的路易斯碱催化剂-醇高效转化为氯化物,胺和醚
标题:甲酰胺作为sn反应中的路易斯碱催化剂-醇高效转化为氯化物,胺和醚
摘要:简单的甲酰胺催化剂可促进以苯甲酰氯为唯一试剂将醇类有效转化为烷基氯.这些亲核取代是通过亚胺基活化的醇作为中间体进行的.这种新颖的方法甚至可以在无溶剂条件下进行,其特点是具有出色的官能团耐受性,可扩展性(> 100 G)和废物平衡(电子因子低至2).手性底物的转化具有优异的立体化学转化水平(99%->>=95%ee).在实际的一锅法中,初步形成的氯化物可以进一步转化为胺,叠氮化物,醚,硫化物和腈.该方法的价值在药物rac ‐ Clopidogrel和s‐芬迪林.
DOI:10.1002/anie.201604921

专利信息

专利号:US-8034966-B1
优先权日:2008-02-20
标 题:Phenoxyisobutyric acid compounds and methods for synthesis
发明人：LALEZARI IRAJ; FABRICANT JILL
权利人:CELL VIABLE CORP
摘要:The present invention provides a process for the synthesis of substituted arylureidophenoxymethylpropionic acid and related compounds including bifunctional and tetrafunctional derivatives. The compounds are useful for inhibiting the formation of AGEs (Aminaglycation end products).

专利号:US-7514465-B2
优先权日:2004-11-16
标题 :Synthesis of N2-(substituted arylmethyl)-3-(substituted phenyl)indazoles as novel anti-angiogenic agents
发明人：KUO SHENG-CHU; HUANG LI-JIAU; LEE FANG-YU; TENG CHE-MING; SHIH MEI-LING; CHEN HUA-SIN
权利人:YUNG SHIN PHARM IND CO LTD
摘要:Novel compounds of 2-(substituted arylmethyl)-3-(substituted phenyl)-2H-indazoles and 1-(substituted arylmethyl)-3-(substituted phenyl)-1H-indazoles are synthesized, and useful as anti-angiogenic agents.

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-4207088-A
优先权日:1977-06-30
标题:Herbicidal 1,3-dioxanes
发明人：KONZ MARVIN J
权利人:FMC CORP
摘要:A new class of herbicidal compounds consisting of 1,3-dioxanes carrying substituents other than hydrogen in the 2-, 4-, 5-, and 6-positions of the dioxane ring exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of selected grassy species. The synthesis of members of this class is described in detail, and the utility of representative compounds in exemplified.

专利号:US-4035178-A
优先权日:1976-08-31
标 题 :Herbicidal 1,3-dioxanes
发明人：KONZ MARVIN JOSEPH
权利人:FMC CORP
摘要:A new class of herbicidal compounds consisting of 1,3-dioxanes carrying substituents other than hydrogen in the 2-, 4-, 5-, and 6-positions of the dioxane ring exhibits preemergence and postemergence herbicidal activity, controlling effectively the growth of selected grassy species. The synthesis of members of this class is described in detail, and the utility of representative compounds is exemplified.

专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.