专利号:US-9126995-B2 优先权日:2011-11-08 标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound 发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU 权利人:NISSAN CHEMICAL IND LTD 摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.
专利号:US-2005130201-A1 优先权日:2003-10-14 标 题 :Splint-assisted enzymatic synthesis of polyribounucleotides 发明人:DERAS MICHAEL; PLEISS JEFFREY A; SCARINGE STEPHEN 权利人:DHARMACON INC 摘要:The present invention comprises methods and compositions for splint-assisted enzymatic synthesis of polyribonucleotides using an RNA polymerizing enzyme. The invention provides ligating ribonucleotides comprising ligating a donor RNA molecule to an acceptor RNA molecule in the presence of RNA ligase and a splint, wherein the donor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety, the acceptor RNA molecule is comprised of at least one nucleotide and a ligation linker moiety and the splint is comprised of a polyribonucleotide. The invention also provides splints for use in splint-assisted enzymatic synthesis using an RNA polymerizing enzyme.
专利号:EP-1373548-B1 优先权日:2002-04-08 标 题 :Chemo-enzymatic synthesis of optically enriched rose-oxides 发明人:TANEJA SHUBASH CHANDRA; SETHI VIJAY KUMAR; KOUL SURRINDER; ANDOTRA SAMAR SINGH; QAZI GHULAM NABI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a process for the synthesis of optically enriched dextro- and leavo-rotatory isomers of rose oxide from racemic citronellol.
专利号:US-7700654-B2 优先权日:2005-02-05 标 题:Isolation of N-butylbenzenesulfonamide, synthesis of benzenesulfonamide derivatives, and use of N-butylbenzenesulfonamide and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma 发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA 权利人:LOHMANN THERAPIE SYST LTS 摘要:A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.
专利号:US-6734313-B2 优先权日:2000-10-20 标题 :Synthesis of spiro esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
专利号:US-6613918-B1 优先权日:2000-10-20 标 题 :Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates 发明人:SEEMAYER ROBERT; LIANG JACK 权利人:BIOAVAILABILITY SYSTEMS LLC 摘要:Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
参考标题:A Novel Rhodium-Catalyzed Domino-Hydroformylation-Reaction For The Synthesis Of Sulphonamides 作者:Kaiwu Dong,Xianjie Fang,Ralf Jackstell,Matthias Beller 摘要:An Efficient And Highly Selective Domino Hydroformylation-Reductive Sulphonamidation Reaction Has Been Developed For The Synthesis Of Sulphonamides Using A Rhodium/phosphine Catalyst.
合成参考文献
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